Genetic susceptibility,environmental risk factors,and incident gastric cancer risk among individuals with different Helicobacter pylori infection status:a population-based studyOA
Gastric cancer(GC)remains a leading cause of cancer mortality worldwide1.Helicobacter pylori(H.pylori)infection is the dominant etiologic factor2,yet GC also arises in individuals without infection or after eradication,suggesting alternative carcinogenic pathways3.Accordingly,increasing attention has been paid to potential differences between H.pylori-negative and-positive GC.Clinicopathologic differences by H.pylori infection status have been reported but most evidence derives from case-control studies in which infection status assessed at diagnosis is prone to misclassification due to prior eradication,spontaneous clearance,or tumor-related changes.As a result,prospective data defining the long-term clinical and biological imprint of baseline H.pylori status are limited.
Hengmin Xu;Hui Ma;Yuxin Wang;Xinling Wang;Xuan Han;Wenjing Zhao;Yang Zhang;Tong Zhou;Jingying Zhang;Weicheng You;Wenqing Li;Kaifeng Pan
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Department of Cancer Epidemiology,Peking University Cancer Hospital&Institute,Beijing 100142,China
医药卫生
carcinogenic pathways accordinglyincreasingprospective dataclinicopathologic differencesgastric cancer gc remainsHelicobacter pylori infectionpopulation based studyenvironmental risk factorsgenetic susceptibility
《Cancer Biology & Medicine》 2026 (7)
P.1038-1043,6
funded by Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(No.ZLRK202325)the Noncommunicable Chronic Diseases National Science and Technology Major Project(Nos.2023ZD0501400,2025ZD0545200)Capital’s Funds for Health Improvement and Research(No.2026-1Q-1091)National Natural Science Foundation of China(Nos82172555,82273704,and 82504482)Beijing Hospitals Authority’s Ascent Plan(DFL20241102)China Postdoctoral Science Foundation(2024M760152)Postdoctoral Fellowship Program of CPSF(GZB20250192)Peking University Medicine Fund for World’s Leading Discipline or Discipline Cluster Development(No.BMU2022XKQ004)Science Foundation of Peking University Cancer Hospital(Nos.BJCH2024BJ02,XKFZ2410,and BJCH2025CZ04)。
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