Association of Chronic Diseases With Herpes Zoster in China:A Nationwide Population-Based SurveyOA
Background:The global burden of herpes zoster(HZ)is rising,posing a major public health challenge,especially among aging populations with high chronic disease prevalence.Although chronic conditions are known risk factors,population-based evidence from China remains scarce.Objective:The aim of the study is to examine the association between chronic diseases and HZ using nationally representative data from China,considering demographic and lifestyle factors.Methods:We conducted a national population-based survey using data from the 2024 China Family Panel Survey.A proba-bility proportional to size sampling method was employed,covering 25 provincial-level administrative divisions and repre-senting 95%of the population in Chinese mainland.A structured questionnaire collected data on HZ diagnosis,chronic disease status,and demographics.Incidence rates were calculated,and multivariable logistic regression was used to estimate adjusted odds ratio(aOR).Results:Among 27,868 participants(21,496 adults;6372 minors),809 adult HZ cases were identified,with 64.40%(n=521)having at least one chronic condition.Female adults with chronic diseases had a higher incidence(12.94/1000 person-years[PY];95%confidence intervals[CI]:11.45–14.56)than males(8.78/1000 PY;95%CI:7.55–10.12).Incidence increased with age,from 8.07/1000 PY(95%CI:4.45–13.10)in those aged 18–29 to 13.36/1000 PY(95%CI:11.08–15.96)in those≥70.Chronic disease was associated with elevated HZ risk(aOR=1.84;95%CI:1.51–2.24).Among 14 chronic conditions,heart disease showed the strongest association(aOR=2.91;95%CI:2.07–4.10),followed by diabetes(aOR=2.04;95%CI:1.48–2.80)and hypertension(aOR=1.89;95%CI:1.47–2.42).Conclusions:Chronic diseases,particularly cardiovascular and metabolic conditions,are significantly associated with increased HZ risk.These findings highlight the need for targeted HZ prevention strategies,including vaccination,among high-risk groups in China.
Wenhui Zhu;Yiqi Xia;Yanran Wang;Zhenyu Shi;Yang Shen;Chengsen Cui;Jinxu Ai;Yemin Yuan;Xin Ye;Dawei Zhu;Ping He
School of Public Health,Peking University,Beijing,China China Center for Health Development Studies,Peking University,Beijing,ChinaSchool of Public Health,Peking University,Beijing,China China Center for Health Development Studies,Peking University,Beijing,ChinaChina Center for Health Development Studies,Peking University,Beijing,ChinaChina Center for Health Development Studies,Peking University,Beijing,ChinaSchool of Public Health,Peking University,Beijing,China China Center for Health Development Studies,Peking University,Beijing,ChinaChina Center for Health Development Studies,Peking University,Beijing,ChinaSchool of Public Health,Peking University,Beijing,China China Center for Health Development Studies,Peking University,Beijing,ChinaChina Center for Health Development Studies,Peking University,Beijing,ChinaInstitute for Global Public Policy,Fudan University,Shanghai,China LSE-Fudan Research Centre for Global Public Policy,Fudan University,Shanghai,ChinaInternational Research Centre for Medicinal Administration(IRCMA),Peking University,Beijing,ChinaChina Center for Health Development Studies,Peking University,Beijing,China Beijing Institute of Health Development,Peking University,Beijing,China National Health Commission Key Laboratory of Health System Reform and Governance,Peking University,Beijing,China State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing,China
医药卫生
chronic diseaseepidemiologyherpes zosternationwide survey
《Health Care Science》 2026 (3)
P.187-195,9
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