The association between HPV infection and endometriosis:Risk and fertility outcomesOA
While infections have been implicated in endometriosis pathogenesis,the role of human papillomavirus(HPV)remains unclear.This study combined a meta-analysis of seven studies with a case-control study(n=432surgically treated patients)to evaluate the association of HPV infection with endometriosis risk and fertility outcomes.The meta-analysis showed no significant association between HPV infection and endometriosis risk,either for any HPV subtype(pooled odds ratio[OR]=2.60,95%confidence interval[CI]:0.28–23.87)or highrisk subtypes(OR=1.68,95%CI:0.49–5.75).Notably,HPV prevalence was higher in patients with endometriosis(46%overall;36%for high-risk subtypes)than in the general population.Evidence regarding the association between HPV infection and fertility outcomes remains limited,with only two eligible studies identified.Our case-control analysis revealed that HPV-positive patients had significantly reduced postoperative live birth rates compared with HPV-negative counterparts(10.6%vs.21.0%,P<0.05).These findings suggest that HPV infection is unlikely to be a major risk factor for endometriosis development,but it may be associated with poorer postsurgical fertility outcomes.The dual-method approach strengthens the evidence for HPV''s clinical impact on reproductive prognosis in patients with existing endometriosis.
Wenqu Li;Zhenlong Wang;Huizhi Qi;Chengjie Xia;Feixue Chen;Juan Xu;Lei Zhang;Xuemei Jia
Department of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,ChinaDepartment of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,ChinaDepartment of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,ChinaDepartment of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,ChinaDepartment of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,ChinaDepartment of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,China Nanjing Medical Key Laboratory of Female Fertility Preservation and Restoration,Nanjing,Jiangsu 210004,ChinaDepartment of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,ChinaDepartment of Gynecology,Women''s Hospital of Nanjing Medical University,Nanjing Women and Children''s Healthcare Hospital,Nanjing,Jiangsu 210004,China Nanjing Medical Key Laboratory of Female Fertility Preservation and Restoration,Nanjing,Jiangsu 210004,China
医药卫生
human papillomavirusendometriosisfemale infertilitypregnancy outcomesmeta-analysiscasecontrol analysis
《The Journal of Biomedical Research》 2026 (4)
P.383-394,I0004-I0005,14
supported by the National Natural Science Foundation of China(Grant Nos.82472707 to X.J.and 81901456 to W.L.)the Jiangsu Province Capability Improvement Project through Science,Technology,and Education,the Jiangsu Provincial Medical Key Discipline(Grant No.ZDXK202211 to X.J.)the Jiangsu Province Graduate Practical Innovation Program(Grant No.SJCX24_0759 to Z.W.)。
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