Folic acid combined with DHA ameliorates cognitive function via modulating microglia-mediated neuroimmuneOA
It remains unclear whether folic acid(FA)and docosahexaenoic acid(DHA)could improve cognitive performance by regulating microglia-mediated neuroimmune mechanisms.This study aimed to reveal the underlying mechanisms of FA and DHA supplementation in improving the cognitive performance.A randomized controlled trial was conducted in elderly patients with mild cognitive impairment(MCI)to examine the impact of FA(800μg/day)and DHA(1.2 g/day)on cognitive functions and neuroimmune-related inflammatory cytokines,such as interleukin(IL)-18,IL-1β,IL-17,IL-21,IL-2,and IL-15.Besides,it was further explored whether FA and DHA may enhance cognitive performance by modifying neuroimmune and microglia in Alzheimer''s disease(AD)inflammation mice.Our results found that FA and/or DHA improved cognitive performance and decreased the level of inflammatory cytokines in MCI patients and AD inflammation mice.The combined intervention was more effective than the FA or DHA intervention alone.Meanwhile,FA and/or DHA inhibited the microglia activation and modulated the microglia phenotype,manifested as an increased level of the M2 phenotype and a decreased level of the M1 phenotype.Additionally,the combined intervention with FA and DHA reduced the concentration of C-C motif chemokine ligand 2,C-C motif chemokine receptor 2,and CD8^(+)T cells in brain,but increased the coverage of neurons.More importantly,after microglial depletion using PLX5622,the combined intervention with FA and DHA further improved cognitive performance and reduced the level of inflammatory cytokines.These findings provide compelling evidence that FA and DHA are expected to constitute a promising nutritional intervention strategy for preventing the development of AD by restoring neuroimmune homeostasis through microglial modulation.
Li Huang;Qianfeng Liu;Zewei Ma;Jiayan Xue;Xingzhao Tian;Xinrui Zhao;Yunqin Zheng;Xinru Wei;Xinyue Yu;Yiran Feng;Jiaxin Xiao;Fuzhi Wang;Ruikun He;Yufang Wang;Xiaoyu Mu;Ya Su;Huichao Qu;Lichun Cao;Meilin Zhang;Huan Liu
School of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,ChinaBYHEALTH Institute of Nutrition&Health,Innovation Research and Development Center,Guangzhou 510663,ChinaBYHEALTH Institute of Nutrition&Health,Innovation Research and Development Center,Guangzhou 510663,ChinaDazhangzhuang Community Medical Service Center,Beichen District,Tianjin 300405,ChinaDazhangzhuang Community Medical Service Center,Beichen District,Tianjin 300405,ChinaDazhangzhuang Community Medical Service Center,Beichen District,Tianjin 300405,ChinaShuangjie Community Medical Service Center,Beichen District,Tianjin 300403,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,China Tianjin Key Laboratory of Environment,Nutrition and Public Health,Tianjin Medical University,Tianjin 300070,China Key Laboratory of Prevention and Control of Major Diseases in the Population,Ministry of Education,Tianjin Medical University,Tianjin 300070,ChinaSchool of Public Health,Tianjin Medical University,Tianjin 300070,China Tianjin Key Laboratory of Environment,Nutrition and Public Health,Tianjin Medical University,Tianjin 300070,China Key Laboratory of Prevention and Control of Major Diseases in the Population,Ministry of Education,Tianjin Medical University,Tianjin 300070,China
轻工纺织
Folic acidDocosahexaenoic acidCognitive performanceMicrogliaNeuroimmune mechanisms
《Food Science and Human Wellness》 2026 (6)
P.2656-2672,17
supported by National Natural Science Foundation of China(82173516 and 82473631)。
评论