Mechanism insight into selenium-rich tea mediates the neuroprotective effect on the treatment of Alzheimer''s diseaseOA
Alzheimer''s disease(AD)is a prevalent age-related neurodegenerative disorder caused by a multifactorial etiology,thus dietary intervention plays an important role in the prevention of AD at its early stage.Selenium(Se)-enriched green tea(Se-GT)exhibits benefits for reducing the risk of several diseases.However,few studies were reported on Se-GT in the intervention of AD and its associated mechanism.The current study was designed to investigate the Se-enriched green tea water extract(Se-TE)on the pathologies of triple transgenic AD mice and primary neurons,as well as its potential regulatory mechanism.Our results indicated that Se-TE supplement ameliorated learning and memory impairment of AD mice,and exerted neuroprotective effects,evidenced as by inhibitingβ-amyloid generation via regulating the expression of insulin-degrading enzyme and proliferator-activated receptor y reducing tau hyperphosphorylation via regulating glycogen synthase kinase 3βand protein phosphatase 2A,repairing neuronal injury and reducing neuronal apoptosis via inhibiting endoplasmic reticulum stress and oxidative stress.Our research findings illuminate the advantageous effects of Se-TE in both the prevention and alleviation of AD.
Zhijun He;Xiaoqian Li;Yingqi Cao;Zi Wang;Yuantao Liu;Yuanyuan Ye;Changsheng Luo;Yuqian Qiao;Xiubo Du;Jiazuan Ni;Jie Cai;Qiong Liu
School of Modern Industry for Selenium Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,China Shenzhen Key Laboratory of Marine Biotechnology and Ecology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518055,ChinaShenzhen Key Laboratory of Marine Biotechnology and Ecology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518055,ChinaShenzhen Key Laboratory of Marine Biotechnology and Ecology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518055,ChinaShenzhen Key Laboratory of Marine Biotechnology and Ecology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518055,ChinaSchool of Modern Industry for Selenium Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,ChinaSchool of Modern Industry for Selenium Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,ChinaSchool of Modern Industry for Selenium Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,ChinaSchool of Modern Industry for Selenium Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,ChinaShenzhen Key Laboratory of Marine Biotechnology and Ecology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518055,ChinaShenzhen Key Laboratory of Marine Biotechnology and Ecology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518055,China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,ChinaSchool of Modern Industry for Selenium Science and Engineering,Wuhan Polytechnic University,Wuhan 430023,China Key Laboratory for Deep Processing of Major Grain and Oil,Ministry of Education,Hubei Key Laboratory for Processing and Transformation of Agricultural Products,Wuhan Polytechnic University,Wuhan 430023,ChinaShenzhen Key Laboratory of Marine Biotechnology and Ecology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518055,China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China
轻工纺织
Selenium-enriched green teaAlzheimer’s diseaseAmyloid-βMicrotubule-associated protein tauCognitive impairment
《Food Science and Human Wellness》 2026 (6)
P.2833-2853,21
partially supported by the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2024SHIBS0003)Natural Science Foundation of Hubei Province of China(No.2024AFA085)。
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