Deployment and clearance of microrobots for localized therapy:past,present and futureOA
Microrobots hold great promise for active and localized therapy by enabling precise navigation and intervention in areas inaccessible to conventional medical devices.However,clinical translation remains hindered by challenges such as navigating complex environments,achieving precise control under dynamic physiological conditions,and ensuring safe post-therapy clearance.This minireview encompasses recent advancements,including biohybrid microrobots that merge synthetic and biological components to improve biocompatibility and functionality,and catheter-assisted systems that integrate conventional medical tools with robotics for enhanced precision and adaptability.It also discusses strategies to tackle key challenges,such as propulsion mechanisms,closed-loop control,biodegradable designs,focusing on improving safety,reliability,and clinical applicability.By compiling these developments,this work outlines a roadmap toward autonomous,multifunctional microrobotic systems capable of navigating complex physiological environments and delivering targeted therapies with minimal invasiveness.
Ben Wang;Kai Fung Chan;Philip Wai Yan Chiu;Joseph Jao Yiu Sung;Li Zhang
College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen 518055,ChinaChow Yuk Ho Technology Centre for Innovative Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Hong Kong 999077,ChinaChow Yuk Ho Technology Centre for Innovative Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China Department of Surgery,Chinese University of Hong Kong,Hong Kong 999077,ChinaLee Kong Chian School of Medicine,Nanyang Technological University,Singapore 637371,SingaporeChow Yuk Ho Technology Centre for Innovative Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China Department of Surgery,Chinese University of Hong Kong,Hong Kong 999077,China Department of Mechanical and Automation Engineering,The Chinese University of Hong Kong,Hong Kong 999077,China
医药卫生
microrobotslocalized therapybiohybridmagnetic actuationswarmdegradation
《National Science Review》 2026 (12)
P.305-319,15
supported by the National Key Research and Development Project(2025YFF0521600)the Shenzhen Medical Research Fund(SMRF,A2303074)the National Natural Science Foundation of China(52475308)the Hong Kong Research Grants Council(RGC)(RFS2122-4S03,R4015-21,C4038-24 G,N_CUHK472/24,GRF 14209024,GRF 14205823,GRF 14301122,GRF 14300621 and GRF 14203123)the Strategic Topics Grant(STG1/E-401/23-N)the Innovation and Technology Fund(ITS/317/23FP)the CUHK internal grants,and the Guangdong Basic and Applied Basic Research Foundation(2026B1515020076 and 2025A1515012211).
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