Walnut oil ameliorates cognitive impairment in D-galactose-induced aging miceOA
Walnut oil(WO)is rich in polyunsaturated fatty acids,particularlyα-linolenic acid,and various bioactive compounds including phenolics,phytosterols,tocopherols,squalene and melatonin,contributing to its broad health benefits.The present study examined whether WO could attenuate cognitive deficits in D-galactose(D-gal)-induced aging mice.Cognitive performance was evaluated by the Morris water maze and step-through passive avoidance tests.WO significantly reversed the cognitive impairments in D-gal-treated mice,as evidenced by shorted the escape latency and swimming distance in the Morris water maze and by prolonged stepthrough latency with fewer errors in the passive avoidance test.Mechanistically,WO alleviated hippocampal neuronal injury as confirmed by Nissl staining,elevated hippocampal cAMP responsive element binding protein(CREB)activity and brain-derived neurotrophic factor(BDNF)expression,and restored postsynaptic density protein-95(PSD95)levels,thereby facilitating synaptic plasticity.These findings indicate that WO protects mice against D-gal-induced cognitive decline and may represent a nutritional strategy for mitigating aging-associated cognitive dysfunction.
Congcong Ma;Lei Wang;Qingde Huang;Qianchun Deng;Fenghong Huang;Jiqu Xu
Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR China Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR ChinaOil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR China Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR ChinaOil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR China Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR ChinaOil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR China Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR ChinaOil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR China Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR ChinaOil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR China Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan,430062,PR China
轻工纺织
Walnut oilD-galactoseCognitionNeuronal injuryCREBPSD95
《Oil Crop Science》 2026 (2)
P.150-155,6
supported by the Key Technology R&D Program of Shandong Province(2023TZXD069)the Innovation group project of Hubei Province(2023AFA042)the National Natural Science Foundation of China(NSFC-U21A20274)the Earmarked Fund for China Agriculture Research System(CARS-14)the Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2016-OCRI)。
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