FOXK2 gene expression in cancer:Potential regulatory mechanisms and clinical implicationsFOXK2 gene expression in cancer:Potential regulatory mechanisms and clinical implicationsOA
FOXK2 is a transcription factor known to regulate a wide range of biological processes that are critically involved in determining cell fate.Increasing evidence shows aberrant FOXK2 expression in some tumors,with crucial biological and clinical impacts.It is important to note that the molecular mechanisms contributing to FOXK2 gene deregulation are poorly understood for most cancers.In this review,we systematically describe the FOXK2 gene expression profile across distinct tumor types and discuss its potential utility as a prognostic and diagnostic molecular marker.Notably,we explore emerging mechanisms accounting for FOXK2 deregulation,focusing on genetic and transcriptional modifications,such as gene methylation,mutation and copy number variations.
Renata Ivo Vasconcelos;Luciana da Torre Carneiro;Raquel Ciuvalschi Maia;Thaıis Hancio;Gabriela Nestal de Moraes
Instituto de Bioquimica Medica Leopoldo de Meis,Universidade Federal do Rio de Janeiro(UFRJ),Avenida Carlos Chagas Filho,373,2°andar,H2-003,Cidade Universitaria,Rio de Janeiro 21941599,BrazilInstituto de Bioquimica Medica Leopoldo de Meis,Universidade Federal do Rio de Janeiro(UFRJ),Avenida Carlos Chagas Filho,373,2°andar,H2-003,Cidade Universitaria,Rio de Janeiro 21941599,BrazilPrograma de Hemato-Oncologia Molecular,Instituto Nacional do Cancer(INCA),Praca da CruzVermelha,23,6°andar,Centro,Rio de Janeiro 20230130,BrazilLaboratorio Nacional de Biociencias(LNBio),Centro Nacional de Pesquisa em Energia e Materiais(CNPEM),Polo II de Alta Tecnologia,R.Giuseppe Maximo Scolfaro,10000,Bosque das Palmeiras,Campinas,Sao Paulo 13083100,BrazilInstituto de Bioquimica Medica Leopoldo de Meis,Universidade Federal do Rio de Janeiro(UFRJ),Avenida Carlos Chagas Filho,373,2°andar,H2-003,Cidade Universitaria,Rio de Janeiro 21941599,Brazil
医药卫生
CancerClinical outcomesFOXK2 transcriptionfactorGene alterationsTranscript expression
《Genes & Diseases》 2026 (4)
P.305-314,10
supported by grants from L''oreal-UNESCO-ABC For Women in ScienceCarlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro(FAPERJ No.SEI-26003/004812/2021 and SEl-260003/001554/2022)the National Council for Scientific and Technological Development(CNPq No.307427/2022-6 and 408314/2021-4)R.I.V and L.T.C were supported by CNPq fellowships.R.C.M is supported by FAPERJ(No.260003/007036/2022)Our laboratory was also supported by grants from the CNPq-INCT program(No.408340/2024-0)The funding agencies have not been involved in the study design,data collection,analysis and interpretation or writing of the manuscript.
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