Research progress on biomarkers of traumatic brain injuryOA
Traumatic brain injury(TBI)is a common disorder of the nervous system and has become a leading cause of death and disability worldwide,imposing a substantial burden on patients and their social circles.Its main symptoms include dyskinesia,language acquisition difficulties,and cognitive decline.Because of its complexity and diversity,the diagnosis and treatment of TBI have consistently been key areas of focus in medical research.Traditional imaging methods,including X-ray computed tomography(CT)scans and magnetic resonance imaging(MRI),are proficient at identifying overt structural abnormalities;however,their sensitivity in detecting subtle or hidden brain injuries is somewhat restricted.CT is insensitive to nonhemorrhagic lesions and cannot accurately evaluate the degree of injury.The detection rate of microhemorrhagic foci and specific types of TBI by MRI is low;other technologies have complicated operation and high equipment requirements.Therefore,the utilization of biological indicators,or biomarkers,in assessing and predicting the course and outcome of TBI holds immense importance in both diagnostic and prognostic evaluations.This overview reviews the research progress of biomarkers in TBI.Recognizing the significance of TBI-related biomarkers,understanding the pertinent key molecular pathways,and staying informed about the latest advancements in treatment methods are of utmost importance.However,research on TBI biomarkers continues to face challenges.To advance the field,future efforts should focus on delving deeper into the mechanisms,refining more sensitive and tailored detection methodologies,conducting extensive clinical validations,and exploring the potential of personalized treatment plans.
Xuting Shen;Si Cheng;Shuyi Chen;Mengyue Wang;Tangying Li;Weicheng Xu;Yifan Zhang;Ping Yuan;Lei Shi
Department of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,ChinaDepartment of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,ChinaDepartment of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,ChinaDepartment of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,ChinaDepartment of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,ChinaDepartment of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,ChinaDepartment of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,ChinaDepartment of Cardio-Pulmonary Circulation,Innovation and Incubation Center(IIC),Shanghai Pulmonary Hospital,School of Medicine,Tongji University,Shanghai,ChinaDepartment of Clinical Laboratory,Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine,Shanghai,China Department of Human Anatomy,Histology and Embryology,School of Basic Medical Sciences,Xi''an Jiaotong University,Xi''an,Shaanxi,China Institute of Neuroscience,Translational Medicine Institute,Xi''an Jiaotong University Health Science Center,Xi''an,Shaanxi,China
医药卫生
biomarkersdiagnosticshead injuryserum biomarkerstraumatic brain injury(TBI)
《Animal Models and Experimental Medicine》 2026 (6)
P.1065-1104,40
Program of National Natural Science Foundation of China(NSFC),Grant/Award Number:82370057Program of Natural Science Foundation of Shanghai,Grant/Award Number:22ZR1452400Program of Key Research and Development projects in Hainan Province,Grant/Award Number:ZDYF2024SHFZ057。
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