One Health genomics reveals niche-specific lineage replacement in Salmonella EnteritidisOA
Salmonella enterica serovar Enteritidis(S.Enteritidis)is a broad-host-range pathogen posing global challenges to livestock production and public health.However,nation-scale evolutionary dynamics of Enteritidis remain unexplored,considering emerging evidence of human-adaptive traits.Here,we employed a transdisciplinary One Health approach to compile and analyze the largest genomic dataset of S.Enteritidis in China,integrating isolates across human,animal,food,and environmental sectors.Our analyses reveal an alarming escalation in antimicrobial resistance(AMR),with multidrug resistance rates tripling over the two decades.This surge in AMR coincides with the divergent evolution of three major Chinese Mainland lineages:Global-b1,Global-b2,and Global-c.Crucially,we demonstrate that the Global-c lineage has achieved proportional dominance through a process of resistance-driven lineage replacement.This success is fueled by mobile genetic elements and supported by enhanced environmental stress tolerance and metabolic plasticity.Additional SNP-distance mapping uncovered evidence of human-centric dissemination.Collectively,we elucidate the complex,localized adaptation and competitive dynamics of S.Enteritidis lineages.
Haiyang Zhou;Linlin Huang;Jiansen Gong;Chenghao Jia;Qianzhe Cao;Zubin Wang;Yan Song;Jiaqi Chen;Aizhong Chen;Yi Zhang;Abdelaziz Ed-Dra;Yan Li;Guoping Zhao;Min Yue
Department of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,China Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,ChinaDepartment of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,ChinaKey Laboratory for Poultry Genetics and Breeding of Jiangsu Province,Jiangsu Institute of Poultry Sciences,Yangzhou 225125,ChinaDepartment of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,China Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,ChinaDepartment of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,ChinaKey Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,ChinaDepartment of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,ChinaDepartment of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,ChinaKey Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,ChinaKey Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,ChinaLaboratory of Engineering and Applied Technologies,Higher School of Technology,M’ghila Campus,Sultan Moulay Slimane University,Beni Mellal 23000,MoroccoDepartment of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,ChinaKey Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China CAS Key Laboratory of Synthetic Biology,Institute of Plant Physiology and Ecology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China Department of Microbiology and Microbial Engineering,School of Life Sciences,Fudan University,Shanghai 200433,ChinaDepartment of Veterinary Medicine,Zhejiang University College of Animal Sciences,Hangzhou 310058,China Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,National Medical Center for Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China
农业科技
Salmonella Enteritidisgenomicsantimicrobial resistancelineage replacementpopulation evolution
《National Science Review》 2026 (11)
P.165-176,12
supported by the National Natural Science Foundation of China(325B2080 and 32573359)Zhejiang Provincial Natural Science Foundation(LZ24C180002)Hangzhou Chengxi Sci-tech innovation Corridor Management Committeethe Research Funds of Hangzhou Institute for Advanced Study,UCAS.
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