Animal research in the UK:Regulation,implementation,welfare and development of new approach methodologiesOA
Use of animals in biomedical research is still considered essential by many in aca-demia,industry and regulatory authorities.Therefore,it is important that legal,gov-ernance and welfare procedures are in place to ensure that only necessary procedures using animals are carried out and that this occurs within a framework with animal welfare at its core.Animal research in the United Kingdom is conducted under the Animals(Scientific Procedures)Act 1986 and animal research in the United Kingdom has long been seen as a flag bearer for high quality-high welfare research.An example of the leading role taken in supporting animal welfare in research was establishment of the National Centre for the Replacement,Refinement and Reduction of Animals in Research(NC3Rs)to support reducing the scale and impact of animal research.Here,we provide an overview of governance and licensing procedures of animal research in the United Kingdom,coupled with explanations of how excellent welfare underpins high quality research,and examine the development of new approach methodologies.
Ewan St.John Smith;James Bussell;Maggie Gentry;Elliot Lilley;Cathy Merry;Judy MacArthur Clark;William Reynolds
Department of Pharmacology,University of Cambridge,Cambridge,UKBiomedical Services,University of Oxford,Oxford,UKUniversity Biomedical Services,University of Cambridge,Cambridge,UKNational Centre for the Replacement Refinement and Reduction of Animals in Research,London,UKSchool of Medicine,University of Nottingham,Nottingham,UKJMC Welfare International,London,UKStrategic Lead for Science Regulation and Innovation,Home Office,London,UK
生物科学
3RsNew approach methodologiesRegulationWelfare
《Animal Models and Experimental Medicine》 2026 (5)
P.1056-1062,7
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