A review of Pulsatilla decoction:chemical composition,extraction technique and pharmacological activityOA
Infectious diseases pose a severe threat to global human and animal health,as the escalating spread of antimicrobial resistance increasingly undermines conventional public health systems.Natural Chinese herbal formulations offer a promising alternative due to their favorable safety profiles and broad-spectrum bioactivity in vivo.Pulsatilla decoction(PD),a classical traditional Chinese medicine(TCM)formulation,has been historically employed to“clear heat and detoxify,”specifically targeting febrile diseases and enteric infections.Rooted in the“Sovereign–Minister–Assistant-Messenger”(Jun-Chen-Zuo-Shi)hierarchical principle,PD is precisely composed of four herbs:Pulsatilla chinensis(Bunge)Regel(Sovereign),Coptis chinensis Franch.,Phellodendron chinense Schneid.(Minister),and Fraxini Cortex(Assistant).This structured formulation transcends direct pathogen eradication,functioning instead as a sophisticated host-directed therapy.Its therapeutic efficacy stems from synergistic interactions among alkaloids,saponins,and coumarins,which collectively modulate inflammatory signaling cascades(e.g.,TLR4/NF-κB/MAPK),reinforce intestinal barrier integrity,and restore microbial homeostasis.In this review,we provide a comprehensive synthesis of the chemical constituents,extraction techniques,and multi-level mechanisms of action of PD,with a particular focus on the interplay between its phytochemical profile and host-directed anti-inflammatory and intestinal protective effects.This overview aims to offer critical insights into developing alternative strategies to combat bacterial infections by leveraging the synergistic potential of TCM.However,PD’s multi-component nature,unclear precise targets,and variability in extraction methods present challenges for standardization and clinical translation.To advance the application of PD from traditional use to evidence-based applications in both human and veterinary medicine,we have written this review by integrating existing literature.
Yang-Yang Bian;Hui Zhang;Jing-Lan Dou;Jia-Hua He;Ting-Ting Wan;Zhao Liu;Yu-Ting Zhang;Zhuo Li;Hong Dong;Xiao-Ye Liu
College of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 102206,China
医药卫生
traditional Chinese medicine formulaPulsatilla decoctionchemical componentextraction techniquesmechanisms of action
《Traditional Medicine Research》 2026 (12)
P.42-54,13
supported by the Capital Technological Innovation Vouchers(no.H20250278)Evaluation of the Antibiotic-substituting Potential of Hehuan Cimu Oral Liquid(no.H20250063)National Natural Science Foundation of China(no.32202864)Beijing Rural Revitalization Agricultural Science And Technology Project(no.NY2502190225)Young Elite Scientists Sponsorship Program by BAST(no.BYESS2023192)Program of Beijing Municipal Education Commission(no.KM202310020006)Beijing University of Agriculture Science and Technology Innovation Sparkling Support Plan(no.BUA-HHXD2022007).
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