新诊断 2 型糖尿病患者早期动脉粥样硬化的代谢特征OA

Objective To explore the metabolic characteristics of early atherosclerosis in patients with newly diagnosed type 2 diabetes mellitus(T2DM).Methods A total of 198 patients with T2DM who were diagnosed and treated at Changzhou Geriatric Hospital Affiliated to Soochow University from August 2019 to July 2020 were selected.High-frequency ultrasound was used to measure the intima-media thickness(IMT)of the bilateral common carotid arteries,femoral arteries,and common iliac arteries.Based on the presence of plaques or IMT thickening,patients were divided into subclinical atherosclerosis(subAS)group(106 cases)and simple T2DM group(92 cases).Clinical characteristics were compared between two groups,and binary Logistic regression was performed to identify factors influencing subAS in newly diagnosed T2DM patients.Results The detection rate of subAS among the 198 patients was 53.54%(106/198).The age of patients in subAS group was significantly older than that in simple T2DM group,proportions of patients with a history of smoking and hypertension,as well as the levels of systolic blood pressure,body mass index(BMI),glycosylated hemoglobin A1c(HbA1c),2-hour postprandial plasma glucose and triglycerides were all significantly higher than those in simple T2DM group(P<0.05).Binary Logistic regression analysis showed that age,smoking history,history of hypertension,BMI,and HbA1c were independent risk factors for subAS in newly diagnosed T2DM patients(P<0.05).Conclusion The prevalence of subAS in newly diagnosed T2DM patients is relatively high.A strategy of moving the checkpoint forward and taking multiple approaches is expected to block the progression of AS before symptoms appear and improve the long-term prognosis of T2DM patients.