基于倾向性评分匹配的早产儿暂时性甲状腺功能异常对生后早期发育的影响研究OA

Objective To explore the influence of temporary thyroid dysfunction on the early development of premature infants.Methods The data of 163 premature infants admitted to Jinjiang Municipal Hospital from January to December 2024 were collected.According to whether thyroid function was abnormal within 2 weeks after birth,they were divided into abnormal group(n=32)and control group(n=131).To control baseline confounding,propensity score matching was used to match 32 cases with similar baseline characteristics in abnormal group at a ratio of 1:1.The differences in physical development and neuropsychological development of two groups of premature infants 42 days after birth before and after matching were compared.Neuropsychological development was evaluated using the development screen test(DST)for children aged 0-6 and the children neuropsychological and behavioral scale(CNBS).Results Before matching,the Z values of body weight,body length and head circumference of premature infants in abnormal group were significantly lower than those in control group,and the abnormal rates of DST and CNBS were significantly higher than those in control group(P<0.001).After matching,the Z values of body weight,body length and head circumference of premature infants in abnormal group were significantly lower than those in control group,and the abnormal rate of CNBS was significantly higher than that in control group(P<0.05).Multiple regression showed that abnormal thyroid function indicators were independent related factors for decreased body weight Z value and increased risk of abnormal CNBS(P<0.05).Conclusion After controlling for confounding factors,temporary thyroid dysfunction remains an independent related factor for the delayed physical and neuropsychological development of premature infants on 42 days after birth,suggesting that it should be regarded as a key clinical early warning signal,and early development monitoring and intervention for such high-risk infants should be strengthened.