血管内皮生长因子C参与脑膜淋巴管介导β淀粉样蛋白清除的研究进展OA
Research progress on vascular endothelial growth factor C in meningeal lymphatic vessel-mediated clearance of amyloid β-protein
阿尔茨海默病(AD)是一种以β淀粉样蛋白(Aβ)沉积为核心病理改变的神经退行性疾病.脑膜淋巴管是Aβ清除的重要通路,其功能障碍加速AD进展.血管内皮生长因子C(VEGF-C)通过激活血管内皮生长因子受体3及下游信号通路,协同促进淋巴管新生、增强淋巴管通透性及调节淋巴液流动,提高Aβ清除效率.遗传因素和衰老相关因素导致VEGF-C衰减进而削弱脑膜淋巴管功能,形成恶性循环.本文综述了VEGF-C调控脑膜淋巴管结构和功能促进Aβ清除的作用机制,总结了遗传和衰老通过影响VEGF-C导致脑膜淋巴管功能障碍的证据,并展望了基于VEGF-C调控脑膜淋巴管的AD个体化干预策略,以期为AD防治研究提供参考.
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by the abnormal deposition of amyloid β-protein(Aβ)as a core pathological feature.Meningeal lymphatic vessels are crucial for Aβ clearance,and their dysfunction accelerates AD progression.Vascular endothelial growth factor C(VEGF-C),through activation of vascular endothelial growth factor receptor 3 and downstream pathways,synergistically promotes lymphangiogenesis,enhances lymphatic permeability,and regulates lymphatic fluid flow,thereby improving Aβ clearance efficiency.Genetic factors and aging-related declines in VEGF-C further impair meningeal lymphatic function,creating a vicious cycle.This review summarizes the mechanisms by which VEGF-C regulates the structure and function of meningeal lymphatic to promote Aβ clearance,synthesizes the evidence that genetic factors and aging contribute to meningeal lymphatic dysfunction through their effects on VEGF-C,and discusses the prospects of individualized intervention strategies for Alzheimer's disease based on VEGF-C-mediated modulation of meningeal lymphatics,aiming to provide insights for AD prevention and treatment.
於赵勰;汪瑶;李亚楠;沈峰;王彦春
湖北中医药大学针灸骨伤学院,湖北 武汉 430061||湖北时珍实验室,湖北 武汉 430061湖北时珍实验室,湖北 武汉 430061||湖北中医药大学体育健康学院,湖北 武汉 430065湖北中医药大学针灸骨伤学院,湖北 武汉 430061||湖北时珍实验室,湖北 武汉 430061湖北中医药大学针灸骨伤学院,湖北 武汉 430061||湖北时珍实验室,湖北 武汉 430061||针灸治未病湖北省协同创新中心,湖北 武汉 430061||湖北中医药大学附属医院 湖北省中医院针灸科,湖北 武汉 430061湖北时珍实验室,湖北 武汉 430061||湖北中医药大学中医学院,湖北 武汉 430061
医药卫生
阿尔茨海默病血管内皮生长因子脑膜淋巴管β淀粉样蛋白综述
Alzheimer's diseaseVascular endothelial growth factorMeningeal lymphatic vesselAmyloid β-proteinReview
《浙江大学学报（医学版）》 2026 (5)
383-390,8
国家自然科学基金(82405575)湖北省自然科学基金(2023AFD113,2024AFD298)湖北省中医药管理局科研项目(ZY2023F138)湖北省中医药重点学科(针灸学)创新项目(XK202405)湖北中医药大学2025年度博士研究生创新能力提升计划(2025BSCX05)This study was supported by National Natural Science Foundation of China(82405575),Hubei Provincial Natural Science Foundation of China(2023AFD113,2024AFD298),Scientific Research Project of the Hubei Admini-stration of Traditional Chinese Medicine(ZY2023F138),Innova-tion Project of the Key Discipline of Traditional Chinese Medicine(Acupuncture and Moxibustion)in Hubei Province(XK202405),and 2025 Innovation Ability Program for Doctoral Students of Hubei University of Chinese Medicine(2025BSCX05)
评论