再生胰岛衍生蛋白3γ在肠道炎症及肠外疾病中的调控机制与转化潜力OA

Regenerating islet-derived protein 3-gamma(Reg3g),a member of the C-type lectin family,is predomi-nantly expressed in intestinal epithelial cells.Its expression is tightly regulated by multiple factors,including the intestinal microbiota,cytokines,and inflammatory signals.As a key innate immune effector,Reg3g not only exerts direct antibacterial effects by specifically recognizing and binding to peptidoglycan of Gram-positive bacteria but also plays critical roles in maintaining intestinal microbiota homeostasis,enhancing intestinal barrier function,and modulating immune-inflammatory responses.Recent studies have shown that Reg3g also influences the progression of metabolic diseases,liver diseases,and cancers through the gut-organ axis.This article systematically reviews the molecular characteristics and regulatory mechanisms of Reg3g expression,with a focus on its pivotal functions in intestinal inflammation.It further discusses its involvement in extraintestinal diseases and the potential for therapeutic translation,aiming to provide a reference for Reg3g-related basic research and clinical application.