基于"卫气内伐"理论探讨免疫检查点抑制剂相关消化系统毒性的诊治OA

Immune checkpoint inhibitors(ICIs)are one of the breakthrough achievements in the field of tumor immunotherapy,but they also bring a series of immune related adverse reactions.Among them,digestive system toxicity accounts for a considerable proportion.ICIs related gastrointestinal toxicity shares high similarities with autoimmune hepatitis,inflammatory bowel disease,and other rheumatic and autoimmune diseases in terms of pathogenesis,clinical manifestations,and treatment.The theory of"defensive Qi internal logging"originated from the Inner Canon of Huangdi and later became one of the important academic ideas for rheumatic and immune diseases.Drawing on the theory of"defensive Qi internal logging"to analyze the digestive system toxicity of ICIs,it was found that they are related to abnormal ascending and descending,exiting and entering of defensive Qi or insufficient energy of the nutrient Qi.Therefore,diffusing the lung and clearing the intestine to restore the ascending and descending of the defensive Qi,eliminating blood stasis and removing dampness to dredge the channel of defensive Qi movement,soothing liver and regulating Qi to restore the exiting and entering of defensive Qi,replenishing Qi and nourishing blood to nourish the nutrient Qi can restore the normal physiological function of the defensive Qi and achieve the goal of treating ICIs related digestive system toxicity.