基于《金匮要略》血痹理论探讨线粒体自噬与氧化应激调节在膝骨关节炎治疗中的作用OA

Knee osteoarthritis(KOA)is a globally prevalent chronic degenerative joint disease,whose clinical pathogenesis has not been fully elucidated.Recent studies have shown that the vicious cycle formed by the dysregulation of chondrocyte mitophagy and the imbalance of oxidative stress constitutes the core pathological link in the progression of KOA.Tradi-tional Chinese medicine(TCM)has unique advantages in the treatment of KOA.The blood stasis theory from Synopsis of the Golden Chamber takes"deficiency at the root and excess in branch"as its core pathological model,wherein"defi-ciency in root"can correspond to the pathological basis of mitochondrial dysfunction and decreased antioxidant capacity,while"excess in branch"reflects the pathological state of mitophagy dysregulation and oxidative stress imbalance.Based on the blood impediment theory and combined with modern medical research findings,this paper—through a literature re-view and theoretical analysis—proposes that TCM may exert therapeutic effects by regulating the balance between mito-phagy and oxidative stress and disrupting their vicious cycle,thereby providing a theoretical foundation for expanding TCM treatment strategies and mechanistic research on KOA.