补肾除湿方联合关节镜下自体骨软骨移植术治疗膝骨关节炎OA

Objective:To explore the efficacy and safety of the Bushen Chushi formula combined with arthroscopic autolo-gous osteochondral transplantation(AOT)in the treatment of early-to middle-stage knee osteoarthritis(KOA).Meth-ods:The clinical data of 45 patients with knee osteoarthritis,collected from November 2023 to December 2024,were ana-lyzed.Patients were divided into an observation group(n=25)and a control group(n=20)using a random number ta-ble.The WOMAC osteoarthritis pain index scores,Lequesne index scores,knee joint range of motion,and levels of inflam-matory factors were analyzed before surgery,2 weeks after surgery,and 4 weeks after surgery.Results:There was no sta-tistically significant difference in the WOMAC and Lequesne index scores between the two groups before surgery(P>0.05).The WOMAC osteoarthritis pain index scores,Lequesne index scores,and knee joint range of motion of both groups were better than those before surgery 2 weeks and 4 weeks after surgery(P<0.05).There was no statistically significant difference in the serum indicators of interleukin 6(IL-6),matrix metalloproteinase 13(MMP-13),and matrix metalloproteinase 3(MMP-3)between the two groups before surgery(P>0.05).The serum indicators of IL-6,MMP-13,and MMP-3 measured 2 weeks and 4 weeks after surgery were better than those before surgery(P<0.05).Conclusion:The combination of the Bushen Chushi formula and the arthroscopic autologous bone and cartilage transplan-tation surgery can significantly alleviate the pain symptoms of patients with early-to mid-stage knee osteoarthritis and improve the joint function of the affected limb.