中西医结合防治膝骨关节炎的思考OA

Knee osteoarthritis(KOA)is a leading cause of disability among middle-aged and elderly populations globally,emerging as a prominent public health issue with the accelerating aging process.Interventions relying solely on Western or traditional Chinese medicine continue to face numerous bottlenecks,including the absence of disease-modifying osteoarthri-tis drugs(DMOADs),the limitations of single-target therapies,and intractable central sensitization.This paper systemati-cally reviews the systemic advantages of integrating Chinese and Western medicine in KOA prevention and treatment.This integrative model effectively resolves intractable pain sensitization through multi-target synergy;delays cartilage degenera-tion by remodeling the dual homeostasis of macroscopic biomechanics and microscopic immunometabolism;and reduces toxicity while enhancing the efficacy of Western medications throughout whole-course management,deeply empowering enhanced recovery after surgery(ERAS)protocols.Future efforts should focus on strengthening foundational treatments,constructing a"doctor-patient-family"collaborative network,and establishing a multidimensional,high-quality,evidence-based evaluation system,thereby providing a Chinese solution for enhancing the full life-cycle management of KOA.