嘌呤能系统在癫痫机制中的作用及诊疗研究进展OA

Epilepsy is a common chronic neurological disease.Current clinical diagnosis mainly relies on medical history and electroencephalography,which has certain limitations.Existing treatments mainly focus on seizure control but are unable to halt disease progression,and approximately 30%of patients have drug-resistant epilepsy with poor prognosis.In recent years,studies have found that the purinergic system plays an important role in regulating neuronal excitability and neuroinflammation,and the imbalance between the ATP-P2X7R signaling pathway and the adenosine-A1R signaling pathway is involved in the occurrence and development of epilepsy.Molecules related to this system have shown application value in the multi-dimensional diagnosis of epilepsy,and targeted intervention strategies for this system also have broad prospects,but clinical translation still faces challenges.This article systematically reviews the role of the purinergic system in epilepsy,focuses on evaluating its application value in clinical diagnosis and treatment,and provides a theoretical basis and strategies for achieving precision diagnosis and treatment of epilepsy.