猪早期胚胎发育节点、谱系分化机制及发育不均的影响因素OA

As both a vital livestock species and a biomedical model organism,pig serve as a critical system for studying early embryonic development.Understanding this process is significant implications for advancing livestock breeding strategies and developing models for human diseases.However,the signaling pathways,molecular interactions,and regulatory mechanisms—including metabolic regulation—underlying porcine early embryogenesis remain incompletely characterized.This review systematically summarizes key developmental events across successive stages of porcine early embryogenesis,encompassing lineage specification dynamics and associated signaling pathway alterations.Furthermore,we critically examine potential factors contributing to developmental asynchrony in pig embryos,offering mechanistic insights that may enhance mammalian reproductive efficiency and inform human reproductive health research.