力学信号促进牙周再生的分子机制与临床转化OA

The goal of periodontal regeneration is to re-construct a functional periodontal ligament-cementum-alveo-lar bone complex.Previous studies have primarily focused on anti-infection and inflammation control,yet recent evidence indicates that the mechanical microenvironment(e.g.,orth-odontic forces,occlusal load,extracellular matrix stiffness,and viscoelasticity)serves as a critical background variable de-termining cellular fate.Moreover,it can substantially influ-ence regenerative outcomes by modulating the immune micro-environment and bone remodeling processes.At the molecular level,mechanically sensitive ion channels,integrin-focal ad-hesion kinase complexes,and nuclear mechanosensitive struc-tures collectively form a mechano-transduction network that converts mechanical stimuli into Ca2+influx,RhoA/ROCK pathway activation,and transcriptional programs such as YAP/TAZ and β-catenin,thereby precisely regulating periodontal tissue repair and regeneration.At the translational level,bio-materials with programmable mechanical parameters(e.g.,stress relaxation,topological structure)have demonstrated po-tential of regulation beyond spatial maintenance.Clinical stud-ies confirm the feasibility of combined periodontal-orthodon-tic therapy under well-controlled inflammation,where timely and controllable orthodontic mechanical stimuli can be inte-grated into regenerative strategies.This article elaborates on the molecular mechanisms,experimental evidence,and clini-cal translation potential of mechanical signal regulation in periodontal regeneration,aiming to provide new perspectives for clinical decision-making and future research direction in combined periodontal-orthodontic therapy.