毒品记忆和神经突触可塑性在毒品成瘾中的研究进展OA

Drug addiction is a complex neuro-psychiatric disorder involving long-term adaptive brain changes in reward and memory that lead to drug abuse.The interaction between pathological drug memory and neural synaptic plasticity has become the core focus of addiction mechanism research.Pathological drug memory is a highly consolidated and difficult-to-erase conditional memory formed in response to drug-related cues,its abnormal firmness and inability to be forgotten are the key driving factors for relapse behavior.Neural synaptic plasticity mediates long-term neural circuitry modification by drugs through the dynamic synaptic structure and function adjustment.This article reviews the association between pathological drug memory and neural synaptic plasticity and explains the specific molecular and cellular mechanisms of drug memory encoding,consolidation,and retrieval for different types of drugs(including methamphetamine,cocaine,cannabis,heroin,and new psychoactive substances).By examining the specific pathways and targets that regulate different synaptic plasticities,this article aims to provide a theoretical basis and research directions for addiction treatment strategies targeting memory intervention and synaptic plasticity regulation.