乳腺癌动物模型的构建方法及针刺干预效应研究现状OA

Breast cancer is one of the most common and life-threatening malignant tumors among females worldwide,with an increasing annual incidence.Although various treatments are available,issues such as postoperative recurrence,metastasis,and treatment-related side effects continue to significantly impact patient quality of life.As a traditional Chinese therapy,acupuncture offers unique advantages in alleviating breast cancer-related symptoms;however,its direct anti-tumor effects and underlying mechanisms require further clarification.Organizing and comparing ideal and stable animal models are crucial for in-depth research on breast cancer development and progression,as well as for exploring the interventional effects of acupuncture.This article systematically reviews the establishment method,characteristics,and applications of five types of animal models for breast cancer:spontaneous,induced,transplanted,transgenic,and syndrome combination.Types of acupuncture interventions used in animal models,acupuncture parameters,acupoint selection patterns,and evaluation indicators of effects are also summarized.The findings provide a reference for investigating the anti-breast cancer effects and mechanisms of acupuncture,laying an experimental foundation for subsequent research and clinical translation.