线粒体功能受损参与类风湿关节炎病理机制及调控线粒体功能药物的研究进展OA

Mitochondria,known as the"powerhouse"of the cell,plays a vital role not only in cellular metabolism but also as an important intracellular signaling hub.Rheumatoid arthritis(RA)is an inflammatory autoimmune disease with high in-cidence and complex etiology.Mitochondrial dysfunction not only impairs the normal function of immune cells but may also lead to alterations in various forms of cell death,such as apoptosis and autophagy.In RA patients,mitochondrial dysfunction plays a sig-nificant role in the pathological mechanisms of the disease,and restoring mitochondrial function may represent a potential thera-peutic strategy for RA.This article reviewed the molecular mechanisms by which mitochondrial dysfunction participates in the pathological process of RA,as well as the drugs that exert therapeutic effects by regulating mitochondrial activity,aiming to pro-vide new insights and strategies for further understanding the pathogenesis of RA and for the development of RA therapeutics.