拟除虫菊酯暴露与肌肉减少症之间的关联:基于NHANES数据库的横断面研究OA

Objective To explore the relationship between pyrethroid exposure and sarcopenia.Methods Using a cross-sectional study design,the data were sourced from the U.S.National Health and Nutrition Examination Survey conducted from 2011 to 2016.Adults aged 18-59 years were selected as research subjects.Sarcopenia was assessed by calculating the ratio of skeletal muscle mass to body mass index(BMI)using dual-energy X-ray absorptiometry scanning technology.Pyrethroid exposure levels were evaluated based on urinary 3-phenoxybenzoic acid(3-PBA)concentrations.The association between these factors and the risk of sarcopenia,as well as their dose-response relationships,were analyzed using weighted Logistic regression and restricted cubic spline(RCS)models.Subgroup analyses and interaction tests were employed to examine the stability of the findings and the moderating effect of BMI.Results A total of 2,867 participants were included,with a prevalence of sarcopenia at 7.57%.Weighted Logistic regression analysis showed that,after adjusting for covariates,for every one-unit increase in log-transformed 3-PBA exposure level,the risk of sarcopenia increased by 21%[OR=1.21,95%CI(1.02,1.44),P=0.032];Group by quartile of ln(3-PBA),compared with the Q1 group,the Q4 group exhibited a 112%increased risk of sarcopenia[OR=2.12,95%CI(1.22,3.69),P=0.009].RCS analysis revealed a linear positive correlation between 3-PBA and the risk of sarcopenia(Poverall<0.001,Pnonlinearity=0.595),with the risk increase becoming more pronounced when urinary 3-PBA levels exceeded 0.57 μg/L.Subgroup and interaction analyses indicated that this association was stronger in obese individuals with a BMI≥30 kg/m2[OR=1.43,95%CI(1.19,1.71),Ptrend<0.001],and there was an interaction between BMI and 3-PBA on the risk of sarcopenia[OR=1.59,95%CI(1.18,2.14),Pinteraction=0.003].Conclusion There is a positive association between pyrethroid exposure and the risk of sarcopenia,which is particularly evident in obese populations.It is recommended to take multi-level prevention and control measures and further research is needed to improve prevention strategies.