非结核分枝杆菌高风险人群中医药干预疗效评估OA

Objective To establish a quantitative evaluation system for high-risk populations with nontuberculous myco-bacteria(NTM)and to explore the impact of traditional Chinese medicine(TCM)intervention on clinical efficacy,pulmona-ry function,nutritional status and other physical conditions in this population.Methods A retrospective analysis was conducted on 86 high-risk NTM patients who met the inclusion criteria from August 2024 to July 2025.Based on whether they combined TCM treatment and intervention,they were divided into observation group(43 cases)and control group(43 cases).The control group were given standard Western medicine treatment for anti-NTM,while the observation group were given TCM intervention(comprehensive intervention of TCM syndrome differentiation and treatment combined with moxibus-tion and acupoint application)on the basis of conventional treatment for a course of 12 weeks.A self-made NTM high-risk population quantitative assessment scale(including 5 dimensions:6-minute walk test[6-MWT],pulmonary function,BMI,underlying diseases,and mental state)was used to compare various scores,laboratory indicators,and symptom improvement between the two groups before and after treatment.Results Before treatment,there were no statistically significant differ-ences in 6-MWT scores,pulmonary function scores,underlying disease scores,depression scores,and total scores between the two groups(P>0.05).After 12 weeks of treatment,the 6-minute walk distance in the observation group was(412.68±58.32)m,which was significantly increased compared with that([356.42±61.57]m)in the control group,while the pul-monary function score([1.82±0.76]points),underlying disease score([1.12±0.91]points),and depression score([0.87±0.32]points)in the observation group were all lower than those in the control group(P<0.01).Hemoglobin and albumin levels and major symptom remission rates(cough remission rate[90.70％],sputum remission rate[86.05％],and dyspnea remission rate[81.40％])in the observation group were all higher than those in the control group(P<0.05).The total effective rate in the observation group was 88.37％,which was significantly higher than that(67.44％)in the con-trol group(P=0.019).Conclusion TCM intervention can improve the nutritional status,pulmonary function,and exer-cise endurance of high-risk NTM population,reduce the burden of underlying diseases,and significantly alleviate patients'depressive emotions.The clinical efficacy is significant,which provides a reference for the comprehensive prevention and treatment of high-risk NTM populations.