口炎清颗粒联合康复新液治疗复发性口腔溃疡临床研究OA
Clinical Study of Kouyanqing Granules Combined with Kangfuxin Liquid for Recurrent Oral Ulcer
目的:观察口炎清颗粒联合康复新液治疗复发性口腔溃疡的临床疗效.方法:回顾性选取2022年1月—2024年12月于温州医科大学新昌医院治疗的复发性口腔溃疡患者68例,根据治疗方法不同分为研究组和对照组各34例.对照组给予常规治疗,研究组在对照组基础上予口炎清颗粒治疗.2组均治疗2周.评价2组临床疗效,比较2组症状改善时间、睡眠质量和生活质量,检测免疫功能指标及炎症指标水平,统计治疗后3个月和治疗后6个月复发率.结果:研究组总有效率85.29%(29/34),高于对照组58.82%(20/34)(P＜0.05).研究组疼痛持续时间、创面愈合时间、进食改善时间均短于对照组(P＜0.05).治疗后3个月、6个月,研究组复发率低于对照组(P＜0.05).治疗后,2组CD4+、CD4+/CD8+较治疗前升高,CD8+较治疗前降低(P＜0.05);且研究组 CD4+、CD4+/CD8+高于对照组,CD8+低于对照组(P＜0.05).治疗后,2组肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1、IL-6水平较治疗前降低(P＜0.05),且研究组TNF-α、IL-1、IL-6水平低于对照组(P＜0.05).治疗后,2组匹兹堡睡眠质量指数量表(PSQI)评分、视觉模拟评分法(VAS)评分较治疗前降低,生存质量测定量表(QOL-100)评分较治疗前升高(P＜0.05);且研究组PSQI评分、VAS评分低于对照组,QOL-100评分高于对照组(P＜0.05).结论:口炎清颗粒联合康复新液治疗复发性口腔溃疡疗效较好,能显著改善患者的临床症状,提高机体免疫力,改善睡眠质量和生活质量.
Objective:To observe the clinical efficacy of Kouyanqing Granules combined with Kangfuxin Liquid in treating recurrent oral ulcer.Methods:A retrospective study was conducted on 68 patients with recurrent oral ulcer treated at Xinchang Hospital of Wenzhou Medical University from January 2022 to December 2024.They were divided into a study group and a control group according to different treatment methods,with 34 cases in each group.The control group received conventional treatment,while the study group received additional Kouyanqing Granules based on the control group's treatment.Both groups were treated for two weeks.Clinical efficacy was evaluated,and symptom improvement time,sleep quality,and quality of life were compared between the two groups.Immune function indicators and inflammatory markers were measured,and the recurrence rates at three months and six months after treatment were recorded.Results:The total effective rate was 85.29%(29/34)in the study group,higher than that of 58.82%(20/34)in the control group(P＜0.05).The duration of pain,wound healing time,and eating improvement time in the study group were shorter than those in the control group(P＜0.05).At three months and six months after treatment,the recurrence rate in the study group was lower than that in the control group(P＜0.05).After treatment,CD4+and CD4+/CD8+levels increased compared to before treatment in both groups,while CD8+levels decreased(P＜0.05).The study group showed higher CD4+and CD4+/CD8+levels and lower CD8+levels than the control group(P＜0.05).After treatment,tumor necrosis factor-α(TNF-α),interleukin(IL)-1,and IL-6 levels decreased in both groups compared to before treatment(P＜0.05),and the study group had lower levels of these inflammatory markers than the control group(P＜0.05).After treatment,Pittsburgh Sleep Quality Index(PSQI)scores and Visual Analogue Scale(VAS)scores decreased,while Quality of Life Scale-100(QOL-100)scores increased in both groups compared to before treatment(P＜0.05).The study group showed lower PSQI and VAS scores and higher QOL-100 scores than the control group(P＜0.05).Conclusion:Kouyanqing Granules combined with Kangfuxin Liquid has good efficacy in treating recurrent oral ulcer.It significantly improves clinical symptoms,enhances immune function,and improves sleep quality and quality of life.
沈越;鲁超
温州医科大学新昌医院口腔科,浙江 绍兴 312500平湖市第一人民医院口腔科,浙江 平湖 314200
医药卫生
复发性口腔溃疡口炎清颗粒康复新液复发率炎症反应免疫功能生活质量
Recurrent oral ulcerKouyanqing GranulesKangfuxin LiquidRecurrence rateInflammatory responseImmune functionQuality of life
《新中医》 2026 (15)
21-26,6
2023年度平湖市科技计划项目(平科技[2023]21号)
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