同时性双侧乳腺癌的临床病理特征及预后分析OA

Objective To analyze the clinicopathological characteristics and prognosis of primary synchronous bilateral breast cancer(SBBC)based on Shanghai Jiao Tong University Breast Cancer Database,and to explore risk factors of prognosis.Methods This retrospective study enrolled operable SBBC patients from Shanghai Jiao Tong University Breast Cancer Database(January 2009 to June 2022)to assess clinicopathological characteristics,treatments,and survival outcomes.COX proportional hazards regression analysis was used to evaluate the factors influencing prognosis of disease-free survival(DFS)and breast cancer free interval(BCFI).Results A total of 322 cases with SBBC were included.In the first tumor,there were more cases who had tumors with a diameter greater than 2.0 cm,lymph node metastasis,and high Ki-67 index,compared with the second tumor(All P<0.05).And the proportion of progesterone receptor(PR)positivity in the first tumor was lower(P<0.05).The surgical approaches for both breasts showed moderate consistency,with Kappa value of 0.548.There were no significant differences in DFS and BCFI between the cases with bilateral invasive carcinoma and unilateral invasive carcinoma(both P>0.05).Multivariate analysis showed that bilateral lesions with PR negativity was an independent prognostic risk factor associated with DFS(P<0.05)while family history of breast cancer,bilateral lesions with LN 1-3,and bilateral lesions with PR negativity are prognostic risk factors associated with BCFI(P<0.05).Conclusions SBBC patients with PR negativity of bilateral lesions have a poor prognosis,and required close follow-up.