循环肿瘤DNA在乳腺癌精准诊疗中的应用与展望OA
Application and prospects of circulating tumor DNA in the precision diagnosis and treatment of breast cancer
循环肿瘤DNA(ctDNA)是当前临床转化最成熟、研究最深入的液体活检技术.其凭借无创、动态、高特异性的优势,已成为乳腺癌精准诊疗的重要突破方向.本文系统梳理ctDNA的检测方法,重点阐述ctDNA在乳腺癌诊疗不同阶段的应用价值及研究现状,并对ctDNA指导乳腺癌全病程精准管理的未来发展方向进行展望.
Circulating tumor DNA(ctDNA)represents the liquid biopsy technology with the most advanced clinical translation and the deepest research foundation to date.Leveraging its non-invasive,dynamic,and highly specific advantages,ctDNA has emerged as an important breakthrough direction in the precision diagnosis and treatment of breast cancer.In this article,we systematically reviewed the detection methodologies of ctDNA,with a dedicated focus on its clinical utility and current research status across different stages of breast cancer management.Furthermore,we provided a forward-looking perspective on the future development of ctDNA in guiding the full-course precision management of breast cancer.
王豪雨;朱思吉;李安琪;陈小松
上海交通大学医学院附属瑞金医院 普外科 乳腺疾病诊治中心,上海 200025上海交通大学医学院附属瑞金医院 普外科 乳腺疾病诊治中心,上海 200025上海交通大学医学院附属瑞金医院 病理科,上海 200025上海交通大学医学院附属瑞金医院 普外科 乳腺疾病诊治中心,上海 200025
医药卫生
乳腺癌循环肿瘤DNA精准医疗预后预测疗效评估
Breast cancerCirculating tumor DNA(ctDNA)Precision medicinePrognostic predictionEfficacy evaluation
《外科理论与实践》 2026 (3)
212-217,6
国家自然科学基金(82403868,82573726)上海市卫生健康委员会智慧医疗专项研究项目(2025ZHYL003).
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