神经导航联合荧光素钠染色技术在脑胶质瘤切除术中的应用价值研究OA
Application value of neuronavigation combined with fluorescein sodium staining technique in glioma resection
目的:探讨神经导航联合荧光素钠染色技术在脑胶质瘤切除术中的临床应用价值.方法:选取106例脑胶质瘤患者,随机分为对照组和观察组,均行脑胶质瘤切除术治疗,各53例.对照组应用弥散张量成像(DTI)神经导航引导,观察组应用DTI神经导航引导联合术中荧光素钠染色技术.比较两组肿瘤切除程度、围手术期指标,术前及术后6个月脑脊液神经肽水平、简易智力状态检查量表(MMSE)评分以及术后并发症及生存情况.结果:观察组肿瘤全切除率、高级别脑胶质瘤全切除率高于对照组(均P＜0.05).两组低级别脑胶质瘤全切除率比较差异无统计学意义(P＞0.05).术后6个月,观察组脑脊液神经肽水平、MMSE各维度评分改善程度优于对照组(均P＜0.05).观察组手术时间、住院时间、术中出血量少于对照组(均P＜0.05).两组术后颅内感染、肺部感染、癫痫发生率比较差异无统计学意义(均P＞0.05).随访6个月,无死亡病例.结论:DTI神经导航联合荧光素钠染色技术应用于脑胶质瘤切除术可提升脑胶质瘤全切除率,缩短手术时间,减少术中出血,保护神经功能,改善认知功能,且不增加并发症发生风险.
Objective:To investigate the clinical application value of neuronavigation combined with fluorescein sodium staining technique in glioma resection.Methods:A total of 106 patients with glioma were selected and ran-domly divided into control group and observation group,with 53 cases in each group.All patients underwent glioma resection.The control group was guided by diffusion tensor imaging(DTI)neuronavigation,and the observation group was treated with DTI-guided neuronavigation combined with intraoperative fluorescein sodium staining tech-nique.The degree of tumor resection,perioperative indicators,cerebrospinal fluid neuropeptide levels and Mini-Mental State Examination(MMSE)scores before surgery and six months after surgery,as well as postoperative complica-tions and survival status were compared between the two groups.Results:The total tumor resection rate and total re-section rate of high-grade glioma in the observation group were higher than those in the control group(all P＜0.05).There was no statistically significant difference in the total resection rate of low-grade glioma between the two groups(P＞0.05).At six months after surgery,the improvement degree of cerebrospinal fluid neuropeptide levels and MMSE scores of each dimension in the observation group was better than that in the control group(all P＜0.05).The operation time,hospital stay and intraoperative blood loss in the observation group were less than those in the control group(all P＜0.05).There were no statistically significant differences in the incidence of postoperative in-tracranial infection,pulmonary infection and epilepsy between the two groups(all P＞0.05).No death cases occurred during the 6-month follow-up.Conclusion:The application of DTI-guided neuronavigation combined with fluorescein sodium staining technique in glioma resection can increase the total resection rate of glioma,shorten operation time,reduce intraoperative blood loss,protect neurological function,improve cognitive function,and does not increase the risk of complications.
侯庆石;方钦锐;张艳
南方医科大学第十附属医院 东莞市人民医院,广东东莞 523000南方医科大学第十附属医院 东莞市人民医院,广东东莞 523000南方医科大学第十附属医院 东莞市人民医院,广东东莞 523000
医药卫生
脑胶质瘤神经导航弥散张量成像荧光素钠认知功能并发症
GliomaNeuronavigationDiffusion tensor imagingFluorescein sodiumCognitive functionComplications
《陕西医学杂志》 2026 (8)
1075-1079,5
广东省基础与应用基础研究基金资助项目(2023GRZ-120635)
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