血栓弹力图对结直肠癌患者术后发生静脉血栓栓塞症的预测价值OA

Objective:To investigate the influencing factors of postoperative venous thromboembolism(VTE)in patients with colorectal cancer(CRC)and the predictive value of thromboelastography(TEG)parameters for post-operative VTE in CRC patients.Methods:A total of 112 CRC patients who underwent radical surgery for CRC were selected.According to whether VTE occurred within 4 weeks after surgery,they were divided into control group(without VTE,92 cases)and observation group(with VTE,20 cases).The general clinical data,perioperative pa-rameters,preoperative coagulation function and TEG parameters were compared between the two groups.Multivari-ate Logistic regression was used to analyze the risk factors of postoperative VTE in CRC patients.ROC curve was used to analyze the predictive efficacy of TEG parameters for postoperative VTE in CRC patients.Results:The pro-portions of male patients,patients aged≥60 years and patients with hypertension in the observation group were high-er than those in the control group(all P＜0.05).The operation time,intraoperative blood loss,postoperative immo-bilization time,plasma viscosity,fibrinogen(FIB),D-dimer,maximum amplitude(MA value),α-Angle and coagula-tion index(CI value)in the observation group were higher than those in the control group,while the reaction time(R value)and clot formation time(K value)were lower than those in the control group(all P＜0.05).Gender,age,hypertension comorbidity,operation time,intraoperative blood loss,postoperative immobilization time,plasma viscos-ity,FIB,D-dimer,R value,K value and CI value were independent influencing factors for postoperative VTE in CRC patients(all P＜0.05).The AUC of combined prediction of VTE by R value,K value and CI value was higher than the AUC of single indicator prediction(all P＜0.05).Conclusion:TEG parameters R value,K value and CI value are independent influencing factors for postoperative VTE in CRC patients,and the combination of the three can be used for the prediction of postoperative VTE in CRC.