滑膜炎颗粒在膝关节单髁置换术后应用的疗效分析OA

Objective To investigate the clinical efficacy of Huamoyan Granules after unicompartmental knee arthroplasty(UKA).Methods A total of 82 patients who underwent medial UKA for knee osteoarthritis(KOA)at Affiliated Hospital of Hebei University from July 2023 to July 2024 were selected.Among them,35 patients received Huamoyan Granules(medication group)for a course of 1 month,while 47 patients did not(non-medication group).The visual analogue scale(VAS)score at pre-operation and 1 week post-operation,the Knee Society Score(KSS)at pre-operation,1 month post-operation,and the last follow-up,knee range of motion(maximum flexion angle,maximum extension angle)at pre-operation and 3 weeks post-operation,knee swelling degree at pre-operation,1 week post-operation,1 month post-operation,and the last follow-up,as well as serum levels of C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)at pre-operation and 1 week post-operation,were compared between the two groups.Results The patients were followed-up for 6-12 months,with an average of(8.5±1.8)months.At 1 week post-operation,VAS scores,knee swelling degree,CRP,and ESR improved in both groups compared to pre-operative levels.The medication group showed significantly lower VAS scores(4.03±0.57 vs.5.53±0.65),reduced knee swelling(4.02±1.45 cm vs.5.16±1.23 cm),and lower CRP(14.36±1.01 mg/L vs.15.44±1.30 mg/L)and ESR(39.03±2.17 mm/h vs.43.06±3.13 mm/h)compared to the non-medication group(all P<0.05).At 3 weeks post-operation,knee maximum flexion angle improved in both groups versus pre-operation.The medication group achieved a greater flexion angle(118.98±11.52°)than the non-medication group(110.81±12.96°),and a smaller extension lag(8.18±3.37° vs.11.19±3.81°)(all P<0.05).At 1 month post-operation,the KSS was significantly higher in the medication group(82.71±2.50)than in the non-medication group(75.09±2.29)(P<0.05).However,no significant difference was found in knee swelling degree between the two groups(1.51±0.79 cm,1.68±0.88 cm,P>0.05),and no drug-related adverse events occurred during the medication period.At the last follow-up,no significant difference in KSS was observed between the two groups(P>0.05).Conclusion The application of Huamoyan Granules after UKA can reduce early postoperative pain and inflammatory response,improve knee function and range of motion,and promote early rehabilitation with no severe drug-related adverse events observed.However,it does not provide significant additional improvement in mid-term knee function at 3 months or longer post-operation.