非痴呆帕金森病患者睡眠障碍与认知功能障碍相关性研究OA

Objective:To analyze the correlation between sleep disorders and cognitive dysfunction in non-demented Parkinson's disease(PD)patients.Methods:A total of 100 patients with non-demented Parkinson's disease admitted to the Department of Neurology at Tianshui First People's Hospital from June 2023 to December 2025 were selected as the research subjects.Based on whether they were accompanied by mild cognitive impairment(MCI),they were divided into two groups:an observation group(PD with MCI,n=47)and a control group(PD without MCI,n=53).All patients underwent video polysomnography(vPSG)and their daytime sleepiness was assessed using the Epworth Sleepiness Scale(ESS).Results:There were no statistically significant differ-ences in age,gender,years of education,and medication treatment between the two groups(P＞0.05).However,the differences in disease duration and the Movement Disorder Society-Unified Parkinson's Disease Rating Scale(MDS-UPDRS)scores were statis-tically significant(P＜0.05).Statistically significant differences were also observed between the two groups in terms of total sleep time,wake time,sleep latency,the proportion of non-rapid eye movement(NREM)N1 stage,and the proportion of rapid eye move-ment(REM)sleep(P＜0.05).The incidence of sleep disorders was higher in the observation group than that in the control group,and the incidence of rapid eye movement sleep behavior disorder(RBD)was also higher than that in the control group,with statistically significant differences(P＜0.05).In addition,the ESS scores in the observation group were higher than those in the control group,with a statistically significant difference(P＜0.05).Binary logistic regression analysis revealed that disease dura-tion,total sleep time,wake time,the proportion of NREM N1 stage,the proportion of REM sleep,RBD,and the number of sleep disorders were independent influencing factors for the development of MCI in PD patients(P＜0.05).Conclusion:All PD pa-tients with MCI invariably have sleep disorders,and sleep disorders may play a crucial role in the regulation of cognitive impair-ment in PD patients.