疏肝定悸汤加减治疗阵发性房颤疗效研究OA

Objective:To retrospectively evaluate clinical efficacy of modified Shugan Dingji decoction in treating paroxysmal atrial fibrillation.Methods:A retrospective analysis was conducted on patients with liver Qi stagnation-type paroxysmal atrial fibrillation.Based on whether they received modified Shugan Dingji decoction,patients were di-vided into exposed group(conventional Western medicine treatment plus modified Shugan Dingji decoction)and non-exposed group(conventional Western medicine treatment alone).A total of 100 patients were included in each group using 1∶1 propensity score matching.Outcome measures included 24-hour dynamic electrocardiogram,echocardio-graphy,B-type natriuretic peptide,traditional Chinese medicine syndrome scores,and safety indicators of liver and kidney function.Results:The overall response rate in the exposed group(82.00％)was higher than that in the unex-posed group(68.00％),with statistically significant difference(P＜0.05).After treatment,the average ventricular rate and atrial fibrillation burden in the exposed group were both lower than those in the unexposed group(P＜0.05).The average ventricular rate and atrial fibrillation burden in both groups decreased compared with pre-treat-ment levels(P＜0.05).BNP levels in the exposed group were lower than pre-treatment levels(P＜0.05)and lower than those in the unexposed group(P＜0.05).Changes in BNP levels in the unexposed group before and after treat-ment were not statistically significant(P＞0.05).Among echocardiographic parameters,only the ejection fraction in the non-exposure group decreased compared with pre-treatment levels(P＜0.05).Differences in the remaining parameters be-tween and within groups were not statistically significant(P＞0.05).Following treatment,the total TCM syndrome scores in the exposed group significantly lower than that in the non-exposed group(P＜0.01).Total TCM syndrome scores in both groups decreased significantly compared with pre-treatment levels(P＜0.01).There were no significant abnormalities in liv-er or kidney function in either group before or after treatment(P＞0.05).Conclusion:Modified Shugan Dingji decoction sig-nificantly reduces atrial fibrillation burden,average ventricular rate,TCM syndrome scores,and BNP levels in patients with liver Qi stagnation-type paroxysmal atrial fibrillation,contributing to improved clinical symptoms and quality of life.