用于内照射剂量计算的Beagle犬模型构建及相关剂量系数计算OA

To establish a canine voxel model for internal exposure dose calculation based on Monte Carlo method and calculate related dose coefficients.A CT tomographic image of a female Beagle dog was used to identify tissues and organs.The segmented tissues or organs mainly included uterus,ovaries,bladder,spleen,liver,kidney,stomach,gallbladder,heart,lung,thyroid,brain,etc.,and then the same tissue or organ was colored with one color,and finally certain physical attributes were assigned in the Monte Carlo program MCNP.A voxel model was established that could meet the requirements for pre-clinical dose estimation in animal organs.The number of organs in this model was 12 and the voxel size was 1.05 mm×0.68 mm×2 mm.The establishment of a voxel phantom for the Beagle dog lays the foundation for subsequent calculations of dose-related coefficients,including the specific effective energy(SEE)values and absorbed doses for different target organs uniformly distributed with various radiopharmaceuticals.