c-MYC泛癌表达特征及其预后、免疫与基因组稳定性分析OA
A Pan-Cancer Analysis of c-MYC Expression and Its Correlates with Prognosis,Immune Infiltration,and Genomic Stability
为阐明c-MYC在不同肿瘤发生、发展及免疫治疗应答中的作用机制,运用生物信息学方法,系统分析了c-MYC在33种肿瘤组织中的转录及蛋白表达水平,并评估其与患者预后、免疫细胞浸润、肿瘤突变负荷(TMB)及微卫星不稳定性(MSI)的相关性.结果表明:c-MYC在多种肿瘤中呈高表达状态,且与患者预后不良、免疫细胞浸润程度升高、TMB及MSI水平升高显著相关;同时,c-MYC在不同肿瘤中的表达水平及其预后预测价值存在明显异质性.
To explore the mechanism of c-MYC in tumorigenesis,progression and immunotherapy response across diverse cancers,bioinformatics approaches were adopted to systematically analyze the transcriptional and protein expression levels of c-MYC in 33 types of tumor tissues.We further evaluated the correlations of c-MYC expression with patient prognosis,immune cell infiltration,tumor mutational burden(TMB)and microsatellite instability(MSI).The results demonstrated that c-MYC was highly expressed in multiple cancers,and its upregulation was significantly correlated with poor prognosis,increased immune cell infiltration,as well as elevated TMB and MSI levels.In addition,the expression pattern and prognostic predictive value of c-MYC exhibited prominent heterogeneity among different tumor types.
于爽;胡丽鑫;胡斯乐;徐雅楠
内蒙古民族大学 生命科学与食品学院,内蒙古 通辽 028043内蒙古民族大学 生命科学与食品学院,内蒙古 通辽 028043内蒙古民族大学 生命科学与食品学院,内蒙古 通辽 028043内蒙古民族大学 生命科学与食品学院,内蒙古 通辽 028043||内蒙古自治区个体化用药工程技术研究中心,内蒙古 通辽 028000
生物科学
c-MYC肿瘤预后免疫基因组异质性
c-MYCcancer prognosisimmunitygenomic heterogeneity
《内蒙古民族大学学报（自然科学版）》 2026 (4)
17-25,9
国家自然科学基金项目(12104246)内蒙古自治区自然科学基金项目(2024LHMS03016)
评论