黄连及其相关经典方剂和配伍治疗溃疡性结肠炎研究OA
Research Progress of Coptidis Rhizoma and Its Related Classical Prescriptions and Compatibility in the Treatment of Ulcerative Colitis
溃疡性结肠炎(ulcerative colitis,UC)是一种慢性复发性炎症性肠病,西医治疗存在疗效局限,而中医药展现出多靶点、不良反应少等优势.该文总结了黄连及其相关经典方剂和配伍治疗UC 的研究进展.黄连作为治疗UC 的常用中药,其主要活性成分为生物碱类,如小檗碱(berberine)、黄连碱(coptisine)、巴马汀(palmatine)、药根碱(jatrorrhizine)等,可通过调控多条信号通路,如白细胞介素-6(IL-6)/信号转导与转录激活因子3(STAT3)/核因子-κB(NF-κB)、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)、核因子E2相关因子2(Nrf 2)/血红素氧合酶-1(HO-1)等,抑制促炎因子释放,调节肠道菌群平衡,修复肠黏膜屏障,改善免疫细胞失衡,发挥抗炎、抗氧化及调节代谢等作用.含黄连的经典方剂加减,如白头翁汤、乌梅丸、左金丸、黄连干姜汤等及配伍,可通过多维度机制干预UC.白头翁汤可调节免疫、修复屏障及抑制氧化应激;乌梅丸能平衡辅助性T细胞17(Th17)/调节性T细胞(Treg),修复黏膜及抗氧化;左金丸可调控免疫细胞分化及相关信号通路;黄连干姜汤则能调节肠道菌群及代谢,协同抗炎.目前研究仍存在成分机制深度不足、临床转化瓶颈等问题,未来需深入挖掘活性成分,开展多中心研究,以推动黄连及其相关方剂在UC治疗中的应用.
Ulcerative colitis(UC)is a chronic relapsing inflammatory bowel disease.Western medicine treatments have limitations in efficacy,whereas traditional Chinese medicine(TCM)demonstrates advantages such as multi-target effects and fewer adverse reactions.This article summarizes recent research progress on Huanglian(Coptidis Rhizoma)and its related classical formulas and herb pairings in treating UC.As a commonly used TCM herb for UC,the main active components of Huanglian(Coptidis Rhizoma)are alkaloids(e.g.,berberine,coptisine,palmatine,jatrorrhizine).These components exert anti-inflammatory,antioxidant,and metabolic regulatory effects by modulating multiple signaling pathways,such as interleukin-6(IL-6)/signal transducer and activator of transcription 3(STAT3)/nuclear factor-kappa B(NF-κB),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR),and nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1).This modulation inhibits the release of pro-inflammatory cytokines,regulates intestinal microbiota balance,repairs the intestinal mucosal barrier,and improves immune cell imbalance.Modified classical formulas containing Huanglian(Coptidis Rhizoma),e.g.Baitouweng Decoction(白头翁汤),Wumei Pill(乌梅丸),Zuojin Pill(左金丸),Huanglian Ganjiang Decoction(黄连干姜汤)and specific herb pairings intervene in UC through multi-dimensional mechanisms:Baitouweng Decoction regulates immunity,restores barrier function,and inhibits oxidative stress;Wumei Pill balances T helper cell 17(Th17)/regulatory T cell(Treg)ratios,repairs mucosa,and exerts antioxidant effects;Zuojin Pill regulates immune cell differentiation and related signaling pathways;Huanglian Ganjiang Decoction modulates gut microbiota and metabolism,synergistically combating inflammation.Current research still faces challenges,including insufficient depth in understanding component mechanisms and bottlenecks in clinical translation.Future studies should focus on in-depth exploration of active components and conducting multi-center clinical trials to advance the application of Huanglian(Coptidis Rhizoma)and its related formulas in UC treatment.
柴金源;张瑜;张婵;余帅锋;陈震;李鲜
河南中医药大学,河南 郑州 450046河南省中医院,河南中医药大学第二附属医院,河南 郑州 450053河南中医药大学,河南 郑州 450046河南中医药大学,河南 郑州 450046河南中医药大学,河南 郑州 450046河南省中医院,河南中医药大学第二附属医院,河南 郑州 450053
医药卫生
溃疡性结肠炎黄连作用机制
ulcerative colitisHuanglian(Coptidis Rhizoma)mechanism of action
《辽宁中医药大学学报》 2026 (8)
36-43,8
全国名老中医药专家传承工作室项目(国中医药人教函[2022]75号)国家中医药管理局科技项目(GZY-KJS-2022-047-3,GZY-KJS-2023-014)河南省中医药科学研究专项(2023ZY1012)第二批国家中医临床研究基地项目(2021JDZΧ2040)
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