CD64指数联合IL-6和白蛋白对结直肠癌术后切口感染的预测价值OA
Predictive value of CD64 index combined with IL-6 and albumin for postoperative surgical site infection in colorectal cancer
目的 探讨CD64指数联合白细胞介素-6(IL-6)和白蛋白对结直肠癌术后切口感染的预测价值.方法 回顾性分析2021年6月—2025年6月邢台医学院第二附属医院523例接受结直肠癌根治术患者的临床资料,根据术后是否发生切口感染分为感染组与未感染组.检测患者术前24 h及术后24 h的CD64指数、IL-6、白蛋白水平,采用多因素Logistic回归分析患者结直肠癌根治术后切口感染的独立影响因素,绘制受试者工作特征(ROC)曲线分析CD64指数、IL-6、白蛋白对切口感染的预测价值.结果 结直肠癌根治术后31例患者出现切口感染,其中革兰阴性菌感染24例(77.42%),革兰阳性菌感染7例(22.58%).革兰阴性菌以大肠埃希菌为主,占75.00%(18/24);革兰阳性菌以金黄色葡萄球菌为主,占57.14%(4/7).术后24 h,感染组CD64指数、IL-6高于未感染组,白蛋白低于未感染组(P<0.05).多因素Logistic回归分析显示,术后24 h CD64指数、IL-6、白蛋白均为结直肠癌根治术后切口感染的独立影响因素(P<0.05).ROC曲线分析显示,术后24 h CD64指数、IL-6、白蛋白三项联合预测结直肠癌根治术后切口感染的曲线下面积为0.889(95%CI:0.819,0.958),敏感度为83.90%,特异度为80.93%.结论 术后24 h CD64指数、IL-6及白蛋白均为结直肠癌根治术后切口感染的独立影响因素,三者联合检测可显著提升预测效能,具有较高的临床应用价值.
Objective To investigate the predictive value of the CD64 index combined with interleukin-6(IL-6)and albumin for postoperative surgical site infection(SSI)following colorectal cancer(CRC)surgery.Methods A retrospective analysis was conducted on the clinical data of 523 patients who underwent radical resection for CRC at the Second Affiliated Hospital of Xingtai Medical College from June 2021 to June 2025.Patients were divided into an infection group and a non-infection group based on the presence of postoperative SSI.CD64 index,IL-6,and albumin levels were measured at 24 h preoperatively and 24 h postoperatively.Multivariate logistic regression was used to identify independent risk factors for SSI after radical resection of CRC.Receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of the CD64 index,IL-6,and albumin for SSI.Results SSI occurred in 31 patients after radical resection of CRC,including 24 cases(77.42%)of Gram-negative bacterial infections and 7 cases(22.58%)of Gram-positive bacterial infections.Escherichia coli was the predominant Gram-negative pathogen,accounting for 75.00%(18/24),while Staphylococcus aureus was the predominant Gram-positive pathogen,accounting for 57.14%(4/7).At 24 h postoperatively,the infection group had significantly higher CD64 index and IL-6 levels,and significantly lower albumin levels compared with the non-infection group(P<0.05).Multivariate logistic regression analysis showed that the 24 h postoperative CD64 index,IL-6,and albumin were all independent risk factors for SSI after radical resection of CRC(P<0.05).ROC curve analysis demonstrated that the combination of the three markers—24 h postoperative CD64 index,IL-6,and albumin—yielded an area under the curve(AUC)of 0.889(95%CI:0.819,0.958)for predicting SSI after radical resection of CRC,with a sensitivity of 83.90%and a specificity of 80.93%.Conclusion The 24 h postoperative CD64 index,IL-6,and albumin are all independent risk factors for SSI following radical resection of CRC.The combined detection of these three markers significantly improves predictive efficacy and holds substantial clinical application value.
孟媛媛;吴涛涛;张晓清;郭建义
邢台医学院第二附属医院东院区检验科,河北 邢台 054001邢台医学院第二附属医院东院区心血管内二科,河北 邢台 054001邢台医学院第二附属医院东院区检验科,河北 邢台 054001邢台医学院第二附属医院东院区检验科,河北 邢台 054001
结直肠癌CD64白细胞介素-6白蛋白结直肠癌根治术切口感染影响因素预测价值
colorectal cancerCD64interleukin-6albuminradical resection of colorectal cancersurgical site infectionrisk factorpredictive value
《临床误诊误治》 2026 (15)
49-55,7
邢台市重点研发计划自筹项目(2024ZC81)
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