芒针透刺联合体针治疗脑卒中后偏瘫患者的疗效及对其血清BDNF、VEGF、bFGF水平和运动功能的影响OA
The efficacy of elongated needle penetration acupuncture combined with body acupuncture therapy in treating patients with post-stroke hemiplegia and its effects on serum BDNF,VEGF,bFGF levels and motor function
目的 探讨芒针透刺联合体针治疗脑卒中后偏瘫患者的疗效及对其血清脑源性神经营养因子(BDNF)、血管内皮生长因子(VEGF)及碱性成纤维细胞生长因子(bFGF)水平和运动功能的影响.方法 选取2021年5月至2025年3月在苏州明基医院就诊的96例脑卒中后偏瘫患者作为研究对象,采用随机数字表法将患者分为观察组和对照组,各48例.2组均给予相应的支持治疗和康复训练,对照组采用常规体针治疗,观察组在对照组的基础上进行芒针透刺治疗.评估2组临床疗效,并比较治疗前后肌力变化、运动功能[Fugl-Meyer运动功能评定量表(FMA)评分]和平衡功能[Berg平衡量表(BBS)评分]、神经功能指标(BDNF、VEGF、bFGF)及日常生活能力[改良Barthel指数(MBI)评分].结果 观察组总有效率高于对照组,差异有统计学意义(P<0.05).治疗后2组的Lovett分级改善程度均优于治疗前,且观察组改善程度优于对照组,差异均有统计学意义(P<0.05).治疗后2组上、下肢FMA及BBS、MBI评分均高于治疗前,且观察组上、下肢FMA及BBS、MBI评分均高于对照组,差异均有统计学意义(P<0.05).治疗后2组血清BDNF、VEGF及bFGF水平均高于治疗前,且观察组血清BDNF、VEGF及bFGF水平均高于对照组,差异均有统计学意义(P<0.05).结论 芒针透刺与体针联合治疗脑卒中后偏瘫疗效明显,能提高患者肌力,改善运动能力和平衡能力,促进血清神经功能指标水平提升,进而有助于神经功能修复,提升日常生活能力.
Objective To explore the efficacy of elongated needle penetration acupuncture combined with body acupuncture therapy in treating patients with post-stroke hemiplegia and its effects on serum brain-de-rived neurotrophic factor(BDNF),vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)levels and motor function.Methods A total of 96 patients with post-stroke hemiplegia who visited Suzhou Mingji Hospital from May 2021 to March 2025 were selected as the research subjects.The pa-tients were divided into the observation group and the control group by random number table method,with 48 cases in each group.Both groups were given corresponding supportive treatment and rehabilitation training.The control group received conventional body acupuncture treatment,while the observation group received e-longated needle penetration acupuncture treatment in addition to the control group.The clinical efficacy of the two groups was evaluated,and the changes in muscle strength,motor function[Fugl-Meyer Motor Function Assessment Scale(FMA)scores],balance function[Berg Balance Scale(BBS)scores],neurological function indicators(BDNF,VEGF,bFGF)and daily living ability[Modified Barthel Index(MBI)scores]before and after treatment were compared.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The improvement degree of the Lovett classification in both groups after treatment was better than that before treatment,and the im-provement degree of the observation group was better than that of the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of FMA in the upper and lower limbs,BBS,MBI in both groups were higher than those before treatment,and the scores of FMA in the upper and lower limbs,BBS,MBI in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the serum BDNF,VEGF and bFGF levels of both groups were higher than those before treatment,and the serum BDNF,VEGF and bFGF levels of the observa-tion group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Elongated needle penetration acupuncture combined with body acupuncture acupoint ther-apy has a significant effect on post-stroke hemiplegia,can improve muscle strength,improve motor function and balance ability,promote the improvement of serum neurological function indicators levels,and thereby fa-cilitate neural function repair and enhance daily living ability.
钟秉成;张秀胜;陈芳
苏州明基医院中医科,江苏 苏州 215000南京中医药大学徐州附属医院/徐州市中医院针灸脑病科,江苏 徐州 221000江苏省南通市第一人民医院脑病科,江苏 南通 222001
医药卫生
脑卒中偏瘫芒针透刺体针脑源性神经营养因子血管内皮生长因子碱性成纤维细胞生长因子
strokehemiplegiaelongated needle penetration acupuncturebody acupuncturebrain-derived neurotrophic factorvascular endothelial growth factorbasic fibroblast growth factor
《检验医学与临床》 2026 (15)
2056-2061,6
江苏省科技项目(BL2020107).
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