首发精神分裂症患者血清KLK6、铁调素、PTEN水平与病情严重程度及认知功能受损的关系OA

Objective To investigate the relationship between serum kallikrein 6(KLK6),hepcidin,phos-phatase and tensin homolog(PTEN),and disease severity and cognitive impairment in patients with first-epi-sode schizophrenia.Methods A total of 121 patients with first-episode schizophrenia admitted to the hospital from July 2023 to March 2025 were selected as the schizophrenia group,and 121 people without mental disor-ders who underwent physical examination in the hospital during the same period were selected as the control group.According to the Positive and Negative Syndrome Scale(PANSS)score,the patients were divided into the mild group(60 points≤PANSS score<75 points),the moderate group(75 points≤PANSS score<95 points)and the severe group(PANSS≥95 points).According to the MATRIS neurocognitive test(MCCB)score,the patients were divided into the cognitive impairment group(MCCB score<40 points)and the nor-mal cognitive function group(MCCB score≥40 points).The serum levels of KLK6,hepcidin and PTEN were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the in-fluencing factors of cognitive impairment in first-episode schizophrenia.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum KLK6,hepcidin and PTEN for cognitive im-pairment in patients with first-episode schizophrenia.Results The serum levels of KLK6 and hepcidin in the schizophrenia group were higher than those in the control group,and the level of PTEN was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of serum KLK6 and hepcidin in the severe group were higher than those in the mild and moderate groups,and the levels of serum KLK6 and hepcidin in the moderate group were higher than those in the mild group,and the differences were statistically significant(P<0.05).The serum PTEN level in the severe group was lower than that in the mild and moderate groups,and the serum PTEN level in the moderate group was lower than that in the mild group,and the differences were statistically significant(P<0.05).The serum levels of KLK6,hepcidin and PANSS score in the cognitive impairment group were higher than those in the normal cognitive function group,and the serum level of PTEN was lower than that in the normal cognitive function group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that PANSS score,increased serum KLK6 and hepcidin levels were risk factors for cognitive impairment in patients with first-episode schizophrenia(P<0.05),and increased serum PTEN level was a protective factor for cogni-tive impairment in patients with first-episode schizophrenia(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum KLK6,hepcidin and PTEN combined to predict cognitive impairment in patients with first-episode schizophrenia was 0.953,which was greater than the AUC of serum KLK6,hepci-din and PTEN alone(Z=2.596,2.751,2.493;all P<0.05).Conclusion The serum levels of KLK6 and hep-cidin are increased and the serum level of PTEN is decreased in patients with first-episode schizophrenia.The levels of the three indexes are related to the severity of the disease and cognitive impairment.The combined detection of the three indexes has a higher predictive value for cognitive impairment in patients with first-epi-sode schizophrenia.