中医药调控下丘脑-垂体-肾上腺轴改善应激反应治疗急性高原病的作用机制OA

The occurrence of acute mountain sickness is closely related to the hypoxic conditions in high-altitude environment,particu-larly the impact on physiological functions and the hypothalamic-pituitary-adrenal(HPA)axis.TCM,through its multi-component and multi-target approach,can effectively regulate the function of the HPA axis,thereby improving high-altitude stress responses.However,current research still presents the following shortcomings.Firstly,although the introduction of multi-omics technologies offers novel meth-ods to elucidate the mechanisms of TCM,how to effectively integrate data from different levels remains a significant challenge in practi-cal application.Secondly,the broader clinical application of TCM requires substantial evidence-based medical support to verify its effi-cacy and safety.Therefore,future efforts should focus on effectively integrating multi-level data to clarify the mechanisms of TCM,con-ducting high-quality clinical studies to provide evidence-based medical support,and combining modern medical research methods and technologies to deeply investigate the specific mechanisms through which TCM regulates the HPA axis.These steps are will be essential to enhance the application value of TCM in the treatment of acute mountain sickness.