五苓散治疗神经源性膀胱疗效观察OA
Efficacy Observation of Five Substances Powder with Poria in the Treatment of Neurogenic Bladder
目的:观察五苓散治疗神经源性膀胱的临床疗效.方法:将50 例神经源性膀胱患者按照随机数字表法分为试验组和对照组,每组各25 例.对照组给予标准化膀胱康复治疗方案,试验组在对照组治疗的基础上联合五苓散治疗.比较两组患者的临床疗效及治疗前后中医证候积分、生活质量评分、神经源性膀胱评分、尿动力学指标[最大尿流率(maximum urine flow rate,Qmax)、最大逼尿肌压力(maximum detrusor pressure,Pdet-max)、残余尿量(residual urine volume,RUV)]变化情况.结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后试验组低于对照组,差异具有统计学意义(P<0.05).试验组有效率为92.00％,显著高于对照组的68.00％,差异具有统计学意义(P<0.05).两组患者治疗后躯体功能、心理功能、社会功能及物质生活等生活质量评分高于本组治疗前,且治疗后试验组高于对照组,差异具有统计学意义(P<0.05).两组患者治疗后临床症状评分低于本组治疗前,且治疗后试验组低于对照组,差异具有统计学意义(P<0.05).两组患者治疗后 Qmax、Pdet-max 水平高于本组治疗前,RUV 低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05).结论:五苓散治疗神经源性膀胱,可提高临床疗效及患者的生活质量,改善尿动力学指标.
Objective:To observe the clinical efficacy of Five Substances Powder with Poria in the treatment of neurogenic bladder.Meth-ods:A total of 50 patients with neurogenic bladder were randomly divided into the experimental group and the control group using the random number table,with 25 cases in each group.The control group received standardized bladder rehabilitation therapy,while the ex-perimental group received Modified Five Substances Powder with Poria in addition to the standard treatment.Clinical efficacy,and chan-ges in TCM syndrome scores,quality of life scores,neurogenic bladder symptom scores,and urodynamic parameters[maximum urinary flow rate(Qmax),maximum detrusor pressure(Pdet-max),and residual urine volume(RUV)]before and after treatment were com-pared between the two groups.Results:After treatment,the TCM syndrome scores of both groups were lower than those before treatment;moreover,the scores of the experimental group were lower than those of the control group,with statistically significant differences(P<0.05).The effective rate of the experimental group was 92.00％,much higher than 72.00％of the control group,with a statistically significant difference(P<0.05).QoL scores including physical function,psychological function,social function and material well-being were markedly increased in both groups after treatment,and the experimental group obtained higher scores than the control group,with statistically significant differences(P<0.05).The neurogenic bladder scale scores of the two groups declined after treatment,with a more prominent reduction in the experimental group,with a statistically significant difference(P<0.05).Meanwhile,Qmax and Pdet-max values were increased,while RUV was decreased in both groups compared with baseline.There were statistically significant differ-ences between the two groups after treatment(P<0.05).Conclusion:Five Substances Powder with Poria demonstrates notable thera-peutic efficacy in the treating neurogenic bladder,which can effectively improve clinical outcomes,enhance patients' QoL,and optimize urodynamic parameters.
高福秋;徐双景;徐兰平;罗艳
昆山市康复医院,江苏 昆山 215300昆山市康复医院,江苏 昆山 215300昆山市康复医院,江苏 昆山 215300昆山市康复医院,江苏 昆山 215300
医药卫生
神经源性膀胱五苓散《伤寒论》张仲景
neurogenic bladderFive Substances Powder with PoriaTreatise on Cold Damage DiseasesZhang Zhongjing
《河南中医》 2026 (8)
1169-1174,6
2023年度昆山市中医药科技发展专项项目(KZYY202328)
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