猫细小病毒遗传变异、病毒分型及流行特征研究进展OA

Feline parvovirus(FPV)is a highly pathogenic virus causing feline panleukopenia.With the continuous expansion of its host spectrum and the prominent risk of cross-species transmission,FPV poses a severe threat to the health of both domestic pets and wild animals.This review elaborated on the taxonomic status and genomic structural features of FPV,emphatically analyzed the biological functions and key mutation mechanisms of non-structural proteins(NS1,NS2)and structural proteins(VP1,VP2),as well as the serotypes and genotypes of FPV,and summarized its global epidemic dynamics and regional distribution characteristics.Based on the genetic evolution of FPV,this review summarized the latest research progress in viral structure and functional characteristics,molecular variation mechanisms and global epidemic status,analyzed the challenges existing in current prevention and control strategies,and discussed future research directions,aiming to provide targeted references for the scientific prevention,control and further research of FPV-associated diseases.