噬藻体溶菌机制研究进展OA

Cyanophages,as natural viral predators of cyanobacteria,play a key ecological role in regulating host populations and cyanobacterial blooms.Their lytic mechanisms during the infection cycle directly affect virion re-lease,host death,and infection efficiency.Some cyanophages differ markedly from canonical bacteriophages in ge-nome organization and lysis systems.Taking freshwater Myoviridae cyanophages MaMV-DC and MaMV-DH01 as examples,they do not rely on the canonical closely coupled holin-endolysin gene pair arrangement in the ge-nome.Instead,they accomplish lysis through the coordination of multiple non-canonical lytic proteins that are spa-tially discrete.These proteins are diverse in structure,function,and timing,and exhibit explicit biological activities in heterologous expression systems,including strict negative control groups,reflecting evolutionary adapta-tions of cyanophages to different hosts and environments.