行为生活方式对肺癌化疗疗效及预后的影响OA

Aim:To elucidate the influence of behavioral lifestyle on chemotherapy efficacy and prognosis of lung canc-er.Methods:A total of 256 lung cancer patients who received chemotherapy at the First Affiliated Hospital of Zhengzhou U-niversity from January 2022 to December 2024 were included.Prior to chemotherapy,a behavioral and lifestyle questionnaire was administered,revealing 112 cases with healthy behaviors lifestyles and 144 cases with unhealthy behaviors lifestyles.Objective efficacy and incidence of complications after 4 cycles of chemotherapy were recorded;quality of life was assessed u-sing the Core Questionnaire for Quality of Life 30 before chemotherapy and at 1 month post-chemotherapy;follow-up ended in June 2025,with all-cause mortality and disease progression designated as the end-point events,respectively,K-M survival curves were plotted.Results:Compared with those of the unhealthy group,objective response rate of the healthy group was significantly higher(51.8%vs 38.2%),the incidences of bone marrow suppression,hair loss,liver and kidney damage,and neurotoxicity during chemotherapy was lower(27.7%vs 40.3%,63.4%vs 75.0%,15.2%vs 26.4%,19.6%vs 29.9%),the improvement in physical,role,social,and emotional function scores one month after chemotherapy were all higher(P<0.05).The survival outcomes of the healthy group were superior to those of the unhealthy group(P<0.05).Conclusion:A healthy behavior lifestyle could enhance the efficacy of chemotherapy for lung cancer,improve patients'quality of life,and contribute to a favorable prognosis.