基于"大毒治病,十去其六"构建毒性中药在肿瘤治疗中的应用原则OA

"Severe toxic medicinals treat severe diseases,eliminating six-tenths of pathogenic factors"is o-riginated from Suwen·Wuchang Zheng Da Lun(Plain Questions·Comprehensive Treatise on the Normal Gov-ernance of the Five Constants),which is also the origin of the traditional Chinese medicine(TCM)therapeutic principle of"combating toxins with toxins".It emphasizes that drastic potent medicinals for attacking pathogenic evils must be withdrawn once most pathogens are eliminated to prevent impairment of healthy Qi.Based on the clinical diagnosis and treatment practice of TCM for maligment tumors,this paper holds that severely toxic me-dicinals are an indispensable powerful theriputic weapons for the clinical treatment of difficult and severe disea-ses.Such medicinals should not be discarded merely because of the fear of their adverse effect.However,their application must strictly abide by three core principles:thorough study of medicinal properties to understand tox-icity and apply herbs appropriately;precise syndrome differentiation for formula construction and medication ad-ministration;accurate clinical administration with timely discontinuaion uopn subsidence of symptom.Mean-while,this paper constructs an integrated triple-precision framework of"medicinal recognition-syndrome differ-entiation-therapeutic intervention",which reconciles safety and efficacy in the clinical administration of highly toxic medicinals.This framework helps strengthen TCM's capacity to treat refractory severe diseases and improve corresponding clinical therapeutic effects.