心理应激致生殖功能障碍的动物模型及机制研究进展OA

Psychological stress disrupts reproductive function through a multi-system network,which is a research focus in reproductive medicine.Common methods for modeling chronic psychological stress include chronic restraint stress,chronic unpredictable mild stress,social defeat stress,social isolation stress,and early-life stress.Psychological stress activates the hypothalamic-pituitary-adrenal(HPA)axis while inhibiting the hypothalamic-pituitary-gonadal(HPG)axis,leading to abnormal sex hormone secretion.It also induces oxidative damage and chronic inflammatory responses in reproductive tissues.Gut microbiota dysbiosis further amplifies the stress effect through the gut-brain-gonad axis,and epigenetic modifications mediate the long-term persistence and transgenerational transmission of stress effects.Future efforts should integrate multi-omics technologies to construct the standardized animal models of chronic stress,and to explore early intervention targets and personalized treatment strategies for stress-related reproductive dysfunction,thereby providing a theoretical foundation for clinical prevention and treatment.