血细胞参数联合HIF-1α SA LDH在评估骨髓增生异常综合征病情发展中的价值OA

Objective To investigate the value of hematologic parameters combined with HIF-1α,SA,and LDH in assessing the progression of myelodysplastic syndrome(MDS).Methods This study included 90 MDS patients admitted between July 2021 and December 2024 as the MDS group,further categorized into low-intermediate-risk(n=58)group and high-risk(n=32)group.Another 50 healthy subjects were selected as the control group.The detection indicators included red blood cell count(RBC),hematocrit(Hct),platelet count(PLT),white blood cell count(WBC),as well as the levels of HIF-1α,SA and LDH.Results In the MDS group,PLT,RBC,Hct and WBC were all lower than those in the control group,while the levels of HIF-1α,SA and LDH were significantly increased(P<0.05).Blood cell parameters in the high-risk group were lower than those in the low-intermediate-risk groups,whereas serum indexes were higher(P<0.05).Correlation analysis revealed that the severity of MDS was negatively correlated with blood cell parameters and positively correlated with serum indicators(P<0.05).Logistic regression analysis indicated that blood cell parameters were independent protective factors,and serum indexes were risk factors(P<0.05).ROC curve analysis showed that the combined detection achieved a sensitivity of 86.79%,a specificity of 84.35%and an AUC value of 0.814 in predicting disease progression,which was superior to single index detection(P<0.05).Conclusion The combination of hematologic parameters with HIF-1α,SA,and LDH could be used for MDS diagnosis and progression assessment,with the combined model showing superior predictive performance.